DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

Xueyi Shen; Doretta Caramaschi; Mark J. Adams; Rosie M. Walker; Josine L. Min; Alex Kwong; Gibran Hemani; Miruna C. Barbu; Heather C. Whalley; Sarah E. Harris; Ian J. Deary; Stewart W. Morris; Simon R. Cox; Caroline L. Relton; Riccardo E. Marioni; Kathryn L. Evans; Andrew M. Mcintosh

doi:10.1186/s13073-022-01039-5

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

Xueyi Shen, Doretta Caramaschi, Mark J. Adams, Rosie M. Walker, Josine L. Min, Alex Kwong, Gibran Hemani, Miruna C. Barbu, Heather C. Whalley, Sarah E. Harris, Ian J. Deary, Stewart W. Morris, Simon R. Cox, Caroline L. Relton, Riccardo E. Marioni, Kathryn L. Evans, Andrew M. Mcintosh

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Genome Medicine
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s13073-022-01039-5
Publication status	Published - 31 Mar 2022

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10.1186/s13073-022-01039-5

s13073-022-01039-5Final published version, 2.12 MBLicence: Creative Commons: Attribution (CC-BY)

https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01039-5

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Shen, X., Caramaschi, D., Adams, M. J., Walker, R. M., Min, J. L., Kwong, A., Hemani, G., Barbu, M. C., Whalley, H. C., Harris, S. E., Deary, I. J., Morris, S. W., Cox, S. R., Relton, C. L., Marioni, R. E., Evans, K. L., & Mcintosh, A. M. (2022). DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses. Genome Medicine, 14(1). https://doi.org/10.1186/s13073-022-01039-5

@article{7f86b346d0864fd085a1d76d998f3832,

title = "DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses",

author = "Xueyi Shen and Doretta Caramaschi and Adams, {Mark J.} and Walker, {Rosie M.} and Min, {Josine L.} and Alex Kwong and Gibran Hemani and Barbu, {Miruna C.} and Whalley, {Heather C.} and Harris, {Sarah E.} and Deary, {Ian J.} and Morris, {Stewart W.} and Cox, {Simon R.} and Relton, {Caroline L.} and Marioni, {Riccardo E.} and Evans, {Kathryn L.} and Mcintosh, {Andrew M.}",

note = "Funding Information: The LBC1921 was supported by the United Kingdom{\textquoteright}s Biotechnology and Biological Sciences Research Council (BBSRC), The Royal Society and The Chief Scientist Office of the Scottish Government. The LBC1936 is supported by Age UK (Disconnected Mind project, which supports SEH), the Medical Research Council (G0701120, G1001245, MR/M013111/1, MR/R024065/1) and the University of Edinburgh. Methylation typing of LBC1921 and LBC1936 was supported by Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. SRC and IJD were supported by a National Institutes of Health (NIH) research grant R01AG054628, and SRC is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 221890/Z/20/Z). Funding Information: The UK Medical Research Council and Wellcome (Grant Ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. Part of this data was collected using REDCap, see the REDCap website for details https://projectredcap.org/resources/citations/ ). CLR, DC, JLM and GH are supported by the MRC Integrative Epidemiology Unit at the University of Bristol (MC_UU_00011/5). Funding Information: This work is supported by two Wellcome Trust grants to AMM ( Investigator Award in Science: 220857/Z/20/Z and Strategic Award 104036/Z/14/Z). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. In addition, DNAm profiling was supported by funding from NARSAD (Ref 27404, DMH) and the Royal College of Physicians of Edinburgh (SIM Fellowship, HCW). Genotyping of the GS samples was funded by the MRC and Wellcome Trust [104036/Z/14/Z]. GS also receives support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = mar,

day = "31",

doi = "10.1186/s13073-022-01039-5",

language = "English",

volume = "14",

journal = "Genome Medicine",

issn = "1756-994X",

publisher = "BioMed Central",

number = "1",

}

Shen, X, Caramaschi, D, Adams, MJ , Walker, RM, Min, JL, Kwong, A, Hemani, G, Barbu, MC, Whalley, HC , Harris, SE , Deary, IJ, Morris, SW, Cox, SR, Relton, CL, Marioni, RE , Evans, KL & Mcintosh, AM 2022, 'DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses', Genome Medicine, vol. 14, no. 1. https://doi.org/10.1186/s13073-022-01039-5

TY - JOUR

T1 - DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

AU - Shen, Xueyi

AU - Caramaschi, Doretta

AU - Adams, Mark J.

AU - Walker, Rosie M.

AU - Min, Josine L.

AU - Kwong, Alex

AU - Hemani, Gibran

AU - Barbu, Miruna C.

AU - Whalley, Heather C.

AU - Harris, Sarah E.

AU - Deary, Ian J.

AU - Morris, Stewart W.

AU - Cox, Simon R.

AU - Relton, Caroline L.

AU - Marioni, Riccardo E.

AU - Evans, Kathryn L.

AU - Mcintosh, Andrew M.

N1 - Funding Information: The LBC1921 was supported by the United Kingdom’s Biotechnology and Biological Sciences Research Council (BBSRC), The Royal Society and The Chief Scientist Office of the Scottish Government. The LBC1936 is supported by Age UK (Disconnected Mind project, which supports SEH), the Medical Research Council (G0701120, G1001245, MR/M013111/1, MR/R024065/1) and the University of Edinburgh. Methylation typing of LBC1921 and LBC1936 was supported by Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. SRC and IJD were supported by a National Institutes of Health (NIH) research grant R01AG054628, and SRC is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 221890/Z/20/Z). Funding Information: The UK Medical Research Council and Wellcome (Grant Ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. Part of this data was collected using REDCap, see the REDCap website for details https://projectredcap.org/resources/citations/ ). CLR, DC, JLM and GH are supported by the MRC Integrative Epidemiology Unit at the University of Bristol (MC_UU_00011/5). Funding Information: This work is supported by two Wellcome Trust grants to AMM ( Investigator Award in Science: 220857/Z/20/Z and Strategic Award 104036/Z/14/Z). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. In addition, DNAm profiling was supported by funding from NARSAD (Ref 27404, DMH) and the Royal College of Physicians of Edinburgh (SIM Fellowship, HCW). Genotyping of the GS samples was funded by the MRC and Wellcome Trust [104036/Z/14/Z]. GS also receives support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Publisher Copyright: © 2022, The Author(s).

PY - 2022/3/31

Y1 - 2022/3/31

U2 - 10.1186/s13073-022-01039-5

DO - 10.1186/s13073-022-01039-5

M3 - Article

VL - 14

JO - Genome Medicine

JF - Genome Medicine

SN - 1756-994X

IS - 1

ER -