DNA mismatch repair and colorectal cancer

N J Toft, M J Arends

Research output: Contribution to journalArticlepeer-review

Abstract

Colorectal cancer is the second commonest malignancy in the western world, accounting for 20,000 deaths in the U.K. per year. Over the last 10 years, great strides have been made in our understanding of the molecular controls governing the transition from normal mucosa, through adenoma, and finally to carcinoma. This review focuses on the recently discovered DNA mismatch repair pathway and its role in the development of both sporadic and an inherited form of colorectal cancer, namely hereditary non-polyposis colorectal cancer (HNPCC).
Original languageEnglish
Pages (from-to)123-9
Number of pages7
JournalThe Journal of Pathology
Volume185
Issue number2
DOIs
Publication statusPublished - Jun 1998

Keywords

  • Animals
  • Colorectal Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • DNA Repair
  • DNA Replication
  • DNA-Binding Proteins
  • Humans
  • Mice
  • Microsatellite Repeats
  • MutS Homolog 2 Protein
  • Mutation
  • Proto-Oncogene Proteins

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