DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome

George Poulogiannis, Ian M Frayling, Mark J Arends

Research output: Contribution to journalArticlepeer-review

Abstract

DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC), and is characterized by the loss of function of the MMR pathway. Failure to repair replication-associated errors due to a defective MMR system allows persistence of mismatch mutations all over the genome, but especially in regions of repetitive DNA known as microsatellites, giving rise to the phenomenon of microsatellite instability (MSI). A high frequency of instability at microsatellites (MSI-H) is the hallmark of the most common form of hereditary susceptibility to CRC, known as Lynch syndrome (LS) (previously known as hereditary non-polyposis colorectal cancer syndrome), but is also observed in approximately 15-20% of sporadic colonic cancers (and rarely in rectal cancers). Tumour analysis by both MMR protein immunohistochemistry and DNA testing for MSI is necessary to provide a comprehensive picture of molecular abnormality, for use in conjunction with family history data and other clinicopathological features, in order to distinguish LS from sporadic MMR-deficient CRC. Identification of the gene targets that become mutated in MMR-deficient tumours may explain, at least in part, some of the clinical, pathological and biological features of MSI-H CRCs and holds promise for developing novel therapeutics.
Original languageEnglish
Pages (from-to)167-79
Number of pages13
JournalHistopathology
Volume56
Issue number2
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Base Pair Mismatch
  • Colonic Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • DNA Mismatch Repair
  • DNA Repair-Deficiency Disorders
  • DNA-Binding Proteins
  • Humans
  • Microsatellite Instability
  • Microsatellite Repeats
  • Rectal Neoplasms

Fingerprint Dive into the research topics of 'DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome'. Together they form a unique fingerprint.

Cite this