DNA Modulates Solvent Isotope Effects in a Nanopore

Scott Cockroft; Matthew Watson

doi:10.1039/C5CC01563D

DNA Modulates Solvent Isotope Effects in a Nanopore

Research output: Contribution to journal › Article › peer-review

Abstract

Here we investigate the modulation of solvent isotope effects by the entry of DNA molecules into individual α-haemolysin nanopores. Solvent isotope effects in D2O versus H2O were enhanced (kH/kD ≈ 1.6) compared to the bulk (kH/kD ≈ 1.2), except when the pore was most blocked (kH/kD ≤ 1.1).

Original language	English
Pages (from-to)	12243-12246
Journal	Chemical Communications
Volume	51
Issue number	61
Early online date	23 Jun 2015
DOIs	https://doi.org/10.1039/C5CC01563D
Publication status	Published - 23 Jun 2015

Keywords / Materials (for Non-textual outputs)

nanopores
DNA
isotope effects
solvent effects

Access to Document

10.1039/C5CC01563D

c5cc01563dFinal published version, 2.21 MB

TransPoreT: Transmembrane Molecular Machines
Cockroft, S. (Principal Investigator)
EU government bodies
1/09/13 → 31/08/18
Project: Research
Organic supramolecular chemistry: A Research programme of synthetic molecular motors and machines
Leigh, D. (Principal Investigator)
EPSRC
1/01/10 → 30/12/14
Project: Research

DNA modulates solvent isotope effects in a nanopore
Watson, M. (Creator) & Cockroft, S. (Creator), Edinburgh DataShare, 1 Jul 2015
DOI: 10.7488/ds/277, http://dx.doi.org/10.1039/C5CC01563D
Dataset

Cite this

@article{c531a1eeb3bc450498ff1e2fafa6b0c8,

title = "DNA Modulates Solvent Isotope Effects in a Nanopore",

abstract = "Here we investigate the modulation of solvent isotope effects by the entry of DNA molecules into individual α-haemolysin nanopores. Solvent isotope effects in D2O versus H2O were enhanced (kH/kD ≈ 1.6) compared to the bulk (kH/kD ≈ 1.2), except when the pore was most blocked (kH/kD ≤ 1.1).",

keywords = "nanopores , DNA, isotope effects, solvent effects",

author = "Scott Cockroft and Matthew Watson",

year = "2015",

month = jun,

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doi = "10.1039/C5CC01563D",

language = "English",

volume = "51",

pages = "12243--12246",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - DNA Modulates Solvent Isotope Effects in a Nanopore

AU - Cockroft, Scott

AU - Watson, Matthew

PY - 2015/6/23

Y1 - 2015/6/23

N2 - Here we investigate the modulation of solvent isotope effects by the entry of DNA molecules into individual α-haemolysin nanopores. Solvent isotope effects in D2O versus H2O were enhanced (kH/kD ≈ 1.6) compared to the bulk (kH/kD ≈ 1.2), except when the pore was most blocked (kH/kD ≤ 1.1).

AB - Here we investigate the modulation of solvent isotope effects by the entry of DNA molecules into individual α-haemolysin nanopores. Solvent isotope effects in D2O versus H2O were enhanced (kH/kD ≈ 1.6) compared to the bulk (kH/kD ≈ 1.2), except when the pore was most blocked (kH/kD ≤ 1.1).

KW - nanopores

KW - DNA

KW - isotope effects

KW - solvent effects

U2 - 10.1039/C5CC01563D

DO - 10.1039/C5CC01563D

M3 - Article

SN - 1359-7345

VL - 51

SP - 12243

EP - 12246

JO - Chemical Communications

JF - Chemical Communications

IS - 61

ER -

DNA Modulates Solvent Isotope Effects in a Nanopore

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

TransPoreT: Transmembrane Molecular Machines

Organic supramolecular chemistry: A Research programme of synthetic molecular motors and machines

Datasets

DNA modulates solvent isotope effects in a nanopore ﻿

Cite this

DNA modulates solvent isotope effects in a nanopore