DNA Modulates Solvent Isotope Effects in a Nanopore

Scott Cockroft, Matthew Watson

Research output: Contribution to journalArticlepeer-review


Here we investigate the modulation of solvent isotope effects by the entry of DNA molecules into individual α-haemolysin nanopores. Solvent isotope effects in D2O versus H2O were enhanced (kH/kD ≈ 1.6) compared to the bulk (kH/kD ≈ 1.2), except when the pore was most blocked (kH/kD ≤ 1.1).
Original languageEnglish
Pages (from-to)12243-12246
JournalChemical Communications
Issue number61
Early online date23 Jun 2015
Publication statusPublished - 23 Jun 2015


  • nanopores
  • DNA
  • isotope effects
  • solvent effects


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