DNA motifs that sculpt the bacterial chromosome

Fabrice Touzain, Marie-Agnès Petit, Sophie Schbath, Meriem El Karoui

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

During the bacterial cell cycle, the processes of chromosome replication, DNA segregation, DNA repair and cell division are coordinated by precisely defined events. Tremendous progress has been made in recent years in identifying the mechanisms that underlie these processes. A striking feature common to these processes is that non-coding DNA motifs play a central part, thus 'sculpting' the bacterial chromosome. Here, we review the roles of these motifs in the mechanisms that ensure faithful transmission of genetic information to daughter cells. We show how their chromosomal distribution is crucial for their function and how it can be analysed quantitatively. Finally, the potential roles of these motifs in bacterial chromosome evolution are discussed.
Original languageEnglish
Pages (from-to)15-26
Number of pages12
JournalNature Reviews Microbiology
Issue number1
Early online date16 Dec 2010
Publication statusPublished - 31 Jan 2011

Keywords / Materials (for Non-textual outputs)

  • Bacterial development
  • Bacterial genetics


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