Projects per year
Abstract
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always far exceeds the dimensions of the cells that contain it. Organisms, therefore, use sophisticated machineries to package their genomes. These systems range across kingdoms from a single ultra-powerful rotary motor that spools the DNA into a bacteriophage head, to hundreds of thousands of relatively weak molecular motors that coordinate the compaction of mitotic chromosomes in eukaryotic cells. Recent technological advances, such as DNA proximity-based sequencing approaches, polymer modelling and in vitro reconstitution of DNA loop extrusion, have shed light on the biological mechanisms driving DNA organization in different systems. Here, we discuss DNA packaging in bacteriophage, bacteria and eukaryotic cells, which, despite their extreme variation in size, structure and genomic content, all rely on the action of molecular motors to package their genomes.
Original language | English |
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Pages (from-to) | 785-802 |
Journal | Nature Reviews Genetics |
Volume | 25 |
Early online date | 17 Jun 2024 |
DOIs | |
Publication status | Published - Nov 2024 |
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Dive into the research topics of 'DNA packaging by molecular motors: from bacteriophage to human chromosomes'. Together they form a unique fingerprint.Projects
- 2 Finished
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The role of non-histone proteins in chromosome structure and function during mitosis
1/10/15 → 30/09/21
Project: Research