Do short, frequent DNA sequence motifs mould the epigenome?

Timo Quante, Adrian Bird*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

Abstract

'Epigenome' refers to the panoply of chemical modifications borne by DNA and its associated proteins that locally affect genome function. Epigenomic patterns are thought to be determined by external constraints resulting from development, disease and the environment, but DNA sequence is also a potential influence. We propose that domains of relatively uniform DNA base composition may modulate the epigenome through cell type-specific proteins that recognize short, frequent sequence motifs. Differential recruitment of epigenomic modifiers may adjust gene expression in multigene blocks as an alternative to tuning the activity of each gene separately, thus simplifying gene expression programming.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalNature reviews Molecular cell biology
Volume17
Issue number4
Early online date3 Feb 2016
DOIs
Publication statusPublished - 1 Apr 2016

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