Do tissue-dwelling trypanosomes sustain transmission populations?

Stephen D. Larcombe; Jane C. Munday; Richard Mcculloch

doi:10.1016/j.pt.2024.12.001

Do tissue-dwelling trypanosomes sustain transmission populations?

Stephen D. Larcombe
, Jane C. Munday
, Richard Mcculloch^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite’s major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al. show that extravascular parasites in host tissues many explain this paradox and provide insight into trypanosome transmission.

Original language	English
Pages (from-to)	13-15
Number of pages	3
Journal	Trends in Parasitology
Volume	41
Issue number	1
Early online date	16 Dec 2024
DOIs	https://doi.org/10.1016/j.pt.2024.12.001
Publication status	Published - Jan 2025

Access to Document

10.1016/j.pt.2024.12.001

PIIS1471492224003635Final published version, 201 KBLicence: Creative Commons: Attribution (CC-BY)

https://linkinghub.elsevier.com/retrieve/pii/S1471492224003635

1 Finished
1 Active

Quorum sensing in African trypanosomes
Matthews, K. (Principal Investigator)
Wellcome Trust (Rcl)
1/02/22 → 28/02/29
Project: Research
Challenging trypanosome antigenic variation paradigms using natural systems
Matthews, K. (Principal Investigator), Matthews, K. (Principal Investigator), Morrison, L. (Co-investigator) & Morrison, L. (Co-investigator)
Wellcome Trust (Rcl)
2/04/18 → 1/10/24
Project: Research

Cite this

@article{d06c173d55c9426db43b00334c739c17,

title = "Do tissue-dwelling trypanosomes sustain transmission populations?",

abstract = "Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite{\textquoteright}s major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al. show that extravascular parasites in host tissues many explain this paradox and provide insight into trypanosome transmission.",

author = "Larcombe, \{Stephen D.\} and Munday, \{Jane C.\} and Richard Mcculloch",

year = "2025",

month = jan,

doi = "10.1016/j.pt.2024.12.001",

language = "English",

volume = "41",

pages = "13--15",

journal = "Trends in Parasitology",

issn = "1471-4922",