Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores

Krishna G Aragam, Umesh U Tamhane, Eva Kline-Rogers, Jin Li, Keith A A Fox, Shaun G Goodman, Kim A Eagle, Hitinder S Gurm

Research output: Contribution to journalArticlepeer-review

Abstract

The Thrombolysis in Myocardial Infarction (TIMI) risk scores for Unstable Angina/Non-ST-elevation myocardial infarction (UA/NSTEMI) and ST-elevation myocardial infarction (STEMI) and the Global Registry of Acute Coronary Events (GRACE) risk scores for in-hospital and 6-month mortality are established tools for assessing risk in Acute Coronary Syndrome (ACS) patients. The objective of our study was to compare the discriminative abilities of the TIMI and GRACE risk scores in a broad-spectrum, unselected ACS population and to assess the relative contributions of model simplicity and model composition to any observed differences between the two scoring systems.
Original languageEnglish
Article numbere7947
Number of pages9
JournalPLoS ONE
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 2009

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