Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic

M Higgins, R E Hill, J D West

Research output: Contribution to journalArticlepeer-review


Previous studies have shown that En-1, a homeobox-containing gene, maps close to or at the Dh locus in the mouse. Since homeobox-containing genes are key genes in the control of development the close proximity of En-1 to the developmentally significant gene Dh raised the possibility that the Dh mutation represented a mutant allele of En-1. A genetic analysis involving En-1, Dh, and other chromosome 1 markers (Emv-17, ln and Pep-3) shows that although Dh and En-1 are closely linked they are separable by recombination (4/563). The likely gene order and recombination frequencies of these loci are: ln (5.2 +/- 0.9) Emv-17 (1.1 +/- 0.4) Dh (0.7 +/- 0.4) En-1 (3.0 +/- 0.7) Pep-3. This shows that Dh is not a mutant allele of En-1.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalGenetical Research
Issue number1
Publication statusPublished - Aug 1992


  • Animals
  • Chromosome Mapping
  • Congenital Abnormalities
  • Female
  • Genes, Dominant
  • Genes, Homeobox
  • Genetic Linkage
  • Genetic Markers
  • Limb Deformities, Congenital
  • Male
  • Mice
  • Mice, Mutant Strains
  • Phenotype
  • Recombination, Genetic

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