Dopamine Controls Persistence of Long-Term Memory Storage

Janine I. Rossato, Lia R. M. Bevilaqua, Ivan Izquierdo, Jorge H. Medina, Martin Cammarota*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The paradigmatic feature of long-term memory (LTM) is its persistence. However, little is known about the mechanisms that make some LTMs last longer than others. In rats, a long-lasting fear LTM vanished rapidly when the D1 dopamine receptor antagonist SCH23390 was injected into the dorsal hippocampus 12 hours, but not immediately or 9 hours, after the fearful experience. Conversely, intrahippocampal application of the D1 agonist SK38393 at the same critical post-training time converted a rapidly decaying fear LTM into a persistent one. This effect was mediated by brain-derived neurotrophic factor and regulated by the ventral tegmental area (VTA). Thus, the persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points.

Original languageEnglish
Pages (from-to)1017-1020
Number of pages4
JournalScience
Volume325
Issue number5943
DOIs
Publication statusPublished - 21 Aug 2009

Keywords

  • VENTRAL TEGMENTAL AREA
  • HIPPOCAMPAL SLICES
  • CA1 REGION
  • NEURONS
  • RECEPTORS
  • RAT
  • LTP
  • POTENTIATION
  • INFORMATION
  • ACTIVATION

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