Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines

C L Leen; G R Barclay; D B McClelland; W M Shepherd; D T Langford

Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines

C L Leen, G R Barclay, D B McClelland, W M Shepherd, D T Langford

College of Medicine and Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.

Original language	English
Pages (from-to)	119-24
Number of pages	6
Journal	Journal of Infection
Volume	14
Issue number	2
Publication status	Published - Mar 1987

Keywords

Adolescent
Adult
Chromatography, Affinity
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Male
Middle Aged
Tetanus Antitoxin
Tetanus Toxoid
Vaccination

Cite this

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title = "Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines",

abstract = "Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.",

keywords = "Adolescent, Adult, Chromatography, Affinity, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Male, Middle Aged, Tetanus Antitoxin, Tetanus Toxoid, Vaccination",

author = "Leen, {C L} and Barclay, {G R} and McClelland, {D B} and Shepherd, {W M} and Langford, {D T}",

year = "1987",

month = mar,

language = "English",

volume = "14",

pages = "119--24",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "2",

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TY - JOUR

T1 - Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines

AU - Leen, C L

AU - Barclay, G R

AU - McClelland, D B

AU - Shepherd, W M

AU - Langford, D T

PY - 1987/3

Y1 - 1987/3

N2 - Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.

AB - Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.

KW - Adolescent

KW - Adult

KW - Chromatography, Affinity

KW - Clinical Trials as Topic

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Tetanus Antitoxin

KW - Tetanus Toxoid

KW - Vaccination

M3 - Article

C2 - 3553336

VL - 14

SP - 119

EP - 124

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 2

ER -

Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines

Abstract

Keywords

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