Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines

C L Leen, G R Barclay, D B McClelland, W M Shepherd, D T Langford

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.
Original languageEnglish
Pages (from-to)119-24
Number of pages6
JournalJournal of Infection
Volume14
Issue number2
Publication statusPublished - Mar 1987

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Chromatography, Affinity
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Tetanus Antitoxin
  • Tetanus Toxoid
  • Vaccination

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