Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation

Sophie Van Linthout; Frank Spillmann; Gallia Graiani; Kapka Miteva; Jun Peng; Eline Van Craeyveld; Marco Meloni; Markus Tölle; Felicitas Escher; Aysun Subasigüller; Wolfram Doehner; Federico Quaini; Bart De Geest; Heinz Peter Schultheiss; Carsten Tschöpe

doi:10.1007/s00109-010-0690-6

Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation

Sophie Van Linthout, Frank Spillmann, Gallia Graiani, Kapka Miteva, Jun Peng, Eline Van Craeyveld, Marco Meloni, Markus Tölle, Felicitas Escher, Aysun Subasigüller, Wolfram Doehner, Federico Quaini, Bart De Geest, Heinz Peter Schultheiss, Carsten Tschöpe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The protective effects of high-density lipoprotein (HDL) under lipopolysaccharide (LPS) conditions have been well documented. Here, we investigated whether an effect of HDL on Toll-like receptor 4 (TLR4) expression and signalling may contribute to its endothelial-protective effects and to improved survival in a mouse model of LPS-induced inflammation and lethality. HDL cholesterol increased 1.7-fold (p∈

Original language	English
Pages (from-to)	151-160
Number of pages	10
Journal	Journal of Molecular Medicine
Volume	89
Issue number	2
DOIs	https://doi.org/10.1007/s00109-010-0690-6
Publication status	Published - Feb 2011

Keywords / Materials (for Non-textual outputs)

Endothelial cells
Gene transfer
High-density lipoprotein
Lipopolysaccharide
Toll-like receptor 4

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10.1007/s00109-010-0690-6

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Van Linthout, S., Spillmann, F., Graiani, G., Miteva, K., Peng, J., Van Craeyveld, E., Meloni, M., Tölle, M., Escher, F., Subasigüller, A., Doehner, W., Quaini, F., De Geest, B., Schultheiss, H. P., & Tschöpe, C. (2011). Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. Journal of Molecular Medicine, 89(2), 151-160. https://doi.org/10.1007/s00109-010-0690-6

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title = "Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation",

abstract = "The protective effects of high-density lipoprotein (HDL) under lipopolysaccharide (LPS) conditions have been well documented. Here, we investigated whether an effect of HDL on Toll-like receptor 4 (TLR4) expression and signalling may contribute to its endothelial-protective effects and to improved survival in a mouse model of LPS-induced inflammation and lethality. HDL cholesterol increased 1.7-fold (p∈",

keywords = "Endothelial cells, Gene transfer, High-density lipoprotein, Lipopolysaccharide, Toll-like receptor 4",

author = "\{Van Linthout\}, Sophie and Frank Spillmann and Gallia Graiani and Kapka Miteva and Jun Peng and \{Van Craeyveld\}, Eline and Marco Meloni and Markus T{\"o}lle and Felicitas Escher and Aysun Subasig{\"u}ller and Wolfram Doehner and Federico Quaini and \{De Geest\}, Bart and Schultheiss, \{Heinz Peter\} and Carsten Tsch{\"o}pe",

year = "2011",

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doi = "10.1007/s00109-010-0690-6",

language = "English",

volume = "89",

pages = "151--160",

journal = "Journal of Molecular Medicine",

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Van Linthout, S, Spillmann, F, Graiani, G, Miteva, K, Peng, J, Van Craeyveld, E, Meloni, M, Tölle, M, Escher, F, Subasigüller, A, Doehner, W, Quaini, F, De Geest, B, Schultheiss, HP & Tschöpe, C 2011, 'Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation', Journal of Molecular Medicine, vol. 89, no. 2, pp. 151-160. https://doi.org/10.1007/s00109-010-0690-6

Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. / Van Linthout, Sophie; Spillmann, Frank; Graiani, Gallia et al.
In: Journal of Molecular Medicine, Vol. 89, No. 2, 02.2011, p. 151-160.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation

AU - Van Linthout, Sophie

AU - Spillmann, Frank

AU - Graiani, Gallia

AU - Miteva, Kapka

AU - Peng, Jun

AU - Van Craeyveld, Eline

AU - Meloni, Marco

AU - Tölle, Markus

AU - Escher, Felicitas

AU - Subasigüller, Aysun

AU - Doehner, Wolfram

AU - Quaini, Federico

AU - De Geest, Bart

AU - Schultheiss, Heinz Peter

AU - Tschöpe, Carsten

PY - 2011/2

Y1 - 2011/2

N2 - The protective effects of high-density lipoprotein (HDL) under lipopolysaccharide (LPS) conditions have been well documented. Here, we investigated whether an effect of HDL on Toll-like receptor 4 (TLR4) expression and signalling may contribute to its endothelial-protective effects and to improved survival in a mouse model of LPS-induced inflammation and lethality. HDL cholesterol increased 1.7-fold (p∈

AB - The protective effects of high-density lipoprotein (HDL) under lipopolysaccharide (LPS) conditions have been well documented. Here, we investigated whether an effect of HDL on Toll-like receptor 4 (TLR4) expression and signalling may contribute to its endothelial-protective effects and to improved survival in a mouse model of LPS-induced inflammation and lethality. HDL cholesterol increased 1.7-fold (p∈

KW - Endothelial cells

KW - Gene transfer

KW - High-density lipoprotein

KW - Lipopolysaccharide

KW - Toll-like receptor 4

UR - https://www.scopus.com/pages/publications/79951672051

U2 - 10.1007/s00109-010-0690-6

DO - 10.1007/s00109-010-0690-6

M3 - Article

C2 - 20972769

AN - SCOPUS:79951672051

SN - 0946-2716

VL - 89

SP - 151

EP - 160

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

IS - 2

ER -

Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation

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