Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

Maria Reich; Lina Spomer; Caroline Klindt; Katharina Fuchs; Jan Stindt; Kathleen Deutschmann; Johanna Höhne; Evangelia Liaskou; Johannes R Hov; Tom H. Karlsen; Ulrich Beuers; Joanne Verheij; Sofía Ferreira-Gonzalez; Gideon Hirschfield; Stuart J Forbes; Christoph Schramm; I. Esposito; Dirk Nierhoff; Peter Fickert; Claudia Daniela  Fuchs; Michael Trauner; Maria García-Beccaria; Gisela Gabernet; Sven Nahnsen; Jan-Philipp Mallm; Marina Vogel; Kristina Schoonjans; Tobias Lautwein; Karl Koehrer; Dieter Häussinger; Tom Luedde; Mathias Heikenwalder; Verena Keitel

doi:10.1016/j.jhep.2021.03.029

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

Maria Reich, Lina Spomer, Caroline Klindt, Katharina Fuchs, Jan Stindt, Kathleen Deutschmann, Johanna Höhne, Evangelia Liaskou, Johannes R Hov, Tom H. Karlsen, Ulrich Beuers, Joanne Verheij, Sofía Ferreira-Gonzalez, Gideon Hirschfield, Stuart J Forbes, Christoph Schramm, I. Esposito, Dirk Nierhoff, Peter Fickert, Claudia Daniela FuchsMichael Trauner, Maria García-Beccaria, Gisela Gabernet, Sven Nahnsen, Jan-Philipp Mallm, Marina Vogel, Kristina Schoonjans, Tobias Lautwein, Karl Koehrer, Dieter Häussinger, Tom Luedde, Mathias Heikenwalder, Verena Keitel

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of Hepatology
DOIs	https://doi.org/10.1016/j.jhep.2021.03.029
Publication status	Published - 16 Apr 2021

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Reich, M., Spomer, L., Klindt, C., Fuchs, K., Stindt, J., Deutschmann, K., Höhne, J., Liaskou, E., Hov, J. R., Karlsen, T. H., Beuers, U., Verheij, J., Ferreira-Gonzalez, S., Hirschfield, G., Forbes, S. J., Schramm, C., Esposito, I., Nierhoff, D., Fickert, P., ... Keitel, V. (2021). Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2021.03.029

Reich, Maria ; Spomer, Lina ; Klindt, Caroline ; Fuchs, Katharina ; Stindt, Jan ; Deutschmann, Kathleen ; Höhne, Johanna ; Liaskou, Evangelia ; Hov, Johannes R ; Karlsen, Tom H. ; Beuers, Ulrich ; Verheij, Joanne ; Ferreira-Gonzalez, Sofía ; Hirschfield, Gideon ; Forbes, Stuart J ; Schramm, Christoph ; Esposito, I. ; Nierhoff, Dirk ; Fickert, Peter ; Fuchs, Claudia Daniela ; Trauner, Michael ; García-Beccaria, Maria ; Gabernet, Gisela ; Nahnsen, Sven ; Mallm, Jan-Philipp ; Vogel, Marina ; Schoonjans, Kristina ; Lautwein, Tobias ; Koehrer, Karl ; Häussinger, Dieter ; Luedde, Tom ; Heikenwalder, Mathias ; Keitel, Verena. / Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. In: Journal of Hepatology. 2021.

@article{e399800b38484ee894302ad183c50d03,

title = "Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis",

author = "Maria Reich and Lina Spomer and Caroline Klindt and Katharina Fuchs and Jan Stindt and Kathleen Deutschmann and Johanna H{\"o}hne and Evangelia Liaskou and Hov, {Johannes R} and Karlsen, {Tom H.} and Ulrich Beuers and Joanne Verheij and Sof{\'i}a Ferreira-Gonzalez and Gideon Hirschfield and Forbes, {Stuart J} and Christoph Schramm and I. Esposito and Dirk Nierhoff and Peter Fickert and Fuchs, {Claudia Daniela} and Michael Trauner and Maria Garc{\'i}a-Beccaria and Gisela Gabernet and Sven Nahnsen and Jan-Philipp Mallm and Marina Vogel and Kristina Schoonjans and Tobias Lautwein and Karl Koehrer and Dieter H{\"a}ussinger and Tom Luedde and Mathias Heikenwalder and Verena Keitel",

year = "2021",

month = apr,

day = "16",

doi = "10.1016/j.jhep.2021.03.029",

language = "English",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

}

Reich, M, Spomer, L, Klindt, C, Fuchs, K, Stindt, J, Deutschmann, K, Höhne, J, Liaskou, E, Hov, JR, Karlsen, TH, Beuers, U, Verheij, J, Ferreira-Gonzalez, S, Hirschfield, G, Forbes, SJ, Schramm, C, Esposito, I, Nierhoff, D, Fickert, P, Fuchs, CD, Trauner, M, García-Beccaria, M, Gabernet, G, Nahnsen, S, Mallm, J-P, Vogel, M, Schoonjans, K, Lautwein, T, Koehrer, K, Häussinger, D, Luedde, T, Heikenwalder, M & Keitel, V 2021, 'Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2021.03.029

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. / Reich, Maria; Spomer, Lina; Klindt, Caroline; Fuchs, Katharina; Stindt, Jan; Deutschmann, Kathleen; Höhne, Johanna; Liaskou, Evangelia; Hov, Johannes R; Karlsen, Tom H.; Beuers, Ulrich; Verheij, Joanne; Ferreira-Gonzalez, Sofía; Hirschfield, Gideon; Forbes, Stuart J; Schramm, Christoph; Esposito, I.; Nierhoff, Dirk; Fickert, Peter; Fuchs, Claudia Daniela ; Trauner, Michael; García-Beccaria, Maria; Gabernet, Gisela; Nahnsen, Sven; Mallm, Jan-Philipp; Vogel, Marina; Schoonjans, Kristina; Lautwein, Tobias; Koehrer, Karl; Häussinger, Dieter; Luedde, Tom; Heikenwalder, Mathias; Keitel, Verena.

In: Journal of Hepatology, 16.04.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

AU - Reich, Maria

AU - Spomer, Lina

AU - Klindt, Caroline

AU - Fuchs, Katharina

AU - Stindt, Jan

AU - Deutschmann, Kathleen

AU - Höhne, Johanna

AU - Liaskou, Evangelia

AU - Hov, Johannes R

AU - Karlsen, Tom H.

AU - Beuers, Ulrich

AU - Verheij, Joanne

AU - Ferreira-Gonzalez, Sofía

AU - Hirschfield, Gideon

AU - Forbes, Stuart J

AU - Schramm, Christoph

AU - Esposito, I.

AU - Nierhoff, Dirk

AU - Fickert, Peter

AU - Fuchs, Claudia Daniela

AU - Trauner, Michael

AU - García-Beccaria, Maria

AU - Gabernet, Gisela

AU - Nahnsen, Sven

AU - Mallm, Jan-Philipp

AU - Vogel, Marina

AU - Schoonjans, Kristina

AU - Lautwein, Tobias

AU - Koehrer, Karl

AU - Häussinger, Dieter

AU - Luedde, Tom

AU - Heikenwalder, Mathias

AU - Keitel, Verena

PY - 2021/4/16

Y1 - 2021/4/16

U2 - 10.1016/j.jhep.2021.03.029

DO - 10.1016/j.jhep.2021.03.029

M3 - Article

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

ER -

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

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UKRMP 2: The Engineered Cell Environment

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