Dr. Dolittle and the making of the mitotic spindle

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The intrinsic polarity of microtubules within cells is exploited each time cells divide, Kinesins, microtubule-associated motor proteins, are required to execute the dramatic events of mitosis: bipolar spindle assembly, metaphase chromosome alignment, anaphase chromosome segregation, and separation of spindle poles prior to cytokinesis. Surprisingly kinesin-related proteins have been found to move in either "plus-ward" or "minus-ward" directions along microtubules. Evidence from genetic analyses of simple eukaryotes and in vitro activity assays supports the notion that certain subfamilies of kinesin-related proteins provide antagonistic activities necessary to balance mitotic forces. A recent study by Sharp et al.((1)), sheds further light on the subject by exploiting the genetics and cytology of the fruit fly embryo. BioEssays 21:985-990, 1999. (C) 1999 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)985-990
Number of pages6
Issue number12
Publication statusPublished - Dec 1999


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