Drosophila melanogaster embryonic haemocytes: masters of multitasking

Will Wood, Antonio Jacinto

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Drosophila melanogaster haemocytes constitute the cellular arm of a robust innate immune system in flies. In the adult and larva, these cells operate as the first line of defence against invading microorganisms: they phagocytose pathogens and produce antimicrobial peptides. However, in the sterile environment of the embryo, these important immune functions are largely redundant. Instead, throughout development, embryonic haemocytes are occupied with other tasks: they undergo complex migrations and carry out several non-immune functions that are crucial for successful embryogenesis.

Original languageEnglish
Pages (from-to)542-51
Number of pages10
JournalNature reviews Molecular cell biology
Issue number7
Publication statusPublished - Jul 2007

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Cell Movement/physiology
  • Drosophila melanogaster/cytology
  • Embryo, Nonmammalian
  • Gene Expression Regulation, Developmental
  • Genes, Insect
  • Hematopoiesis/physiology
  • Hemocytes/immunology
  • Models, Biological
  • Phagocytosis/physiology
  • Transcription Factors/physiology
  • Transcription, Genetic


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