Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi

Vijay Bansode, Zuzanna J Drebert, Simon A A Travers, Emmanuel Banda, Anna Molesworth, Amelia Crampin, Bagrey Ngwira, Neil French, Judith R Glynn, Grace P McCormack

Research output: Contribution to journalArticlepeer-review

Abstract

In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.
Original languageEnglish
Pages (from-to)439-44
Number of pages6
JournalAids research and human retroviruses
Volume27
Issue number4
DOIs
Publication statusPublished - 2011

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