Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study

Helen R Stagg; James Brown; Elmira Ibraim; Vija Riekstiņa; Piret Viiklepp; Andra Cīrule; Horia Cocei; Manfred Danilovitš; Gunta Dravniece; Charlotte Jackson; Peter J White

doi:10.1371/journal.pone.0142425

Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study

Helen R Stagg, James Brown, Elmira Ibraim, Vija Riekstiņa, Piret Viiklepp, Andra Cīrule, Horia Cocei, Manfred Danilovitš, Gunta Dravniece, Charlotte Jackson, Peter J White

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate drug susceptibility testing and drug susceptibility testing data are vital to inform the development of comprehensive, flexible, multidrug resistant tuberculosis guidance.

Original language	English
Pages (from-to)	e0142425
Journal	PLoS ONE
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0142425
Publication status	Published - 11 Nov 2015

Keywords / Materials (for Non-textual outputs)

Antitubercular Agents/therapeutic use
Cross-Sectional Studies
Demography
Drug Resistance, Multiple, Bacterial/drug effects
Estonia/epidemiology
Female
Fluoroquinolones/pharmacology
Humans
Latvia/epidemiology
Male
Romania/epidemiology
Tuberculosis, Multidrug-Resistant/drug therapy

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10.1371/journal.pone.0142425

Stagg PLoS One 2015Final published version, 156 KB

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title = "Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study",

abstract = "Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate drug susceptibility testing and drug susceptibility testing data are vital to inform the development of comprehensive, flexible, multidrug resistant tuberculosis guidance. ",

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AU - Stagg, Helen R

AU - Brown, James

AU - Ibraim, Elmira

AU - Riekstiņa, Vija

AU - Viiklepp, Piret

AU - Cīrule, Andra

AU - Cocei, Horia

AU - Danilovitš, Manfred

AU - Dravniece, Gunta

AU - Jackson, Charlotte

AU - White, Peter J

PY - 2015/11/11

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AB - Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate drug susceptibility testing and drug susceptibility testing data are vital to inform the development of comprehensive, flexible, multidrug resistant tuberculosis guidance.

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KW - Cross-Sectional Studies

KW - Demography

KW - Drug Resistance, Multiple, Bacterial/drug effects

KW - Estonia/epidemiology

KW - Female

KW - Fluoroquinolones/pharmacology

KW - Humans

KW - Latvia/epidemiology

KW - Male

KW - Romania/epidemiology

KW - Tuberculosis, Multidrug-Resistant/drug therapy

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JO - PLoS ONE

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ER -

Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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