Dual colour, microarray-based, analysis of 10 000 protease substrates

Juan J. Diaz-Mochon, Laurent Bialy, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

A 10 000 member PNA-encoded library of FRET based peptides was synthesised for global analysis of protease cleavage specificity; analysis was achieved using a DNA microarray and consumed minimal quantities of enzyme (60 pmole) and library (3.5 nmole).

Original languageEnglish
Pages (from-to)3984-3986
Number of pages3
JournalChemical Communications
Issue number38
DOIs
Publication statusPublished - 2006

Keywords

  • COMBINATORIAL LIBRARIES
  • PEPTIDE MICROARRAYS
  • SPECIFICITY
  • ASSAY

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