Dyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging

Assel Baibek, Muhammed Üçüncü, Bryn Short, Gordon Ramage, Annamaria Lilienkampf, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

The clinically used antifungal polyene amphotericin B was conjugated, via the mycosamine and the aglycon moieties, to fluorophores. The Cy5 conjugated probe showed selective labelling of fungi in the presence of bacteria, allowing multiplexed imaging and identification of microbial species in a co-culture of fungi and Gram-positive and Gram-negative bacteria.

Original languageEnglish
Pages (from-to)1899-1902
Number of pages4
JournalChemical Communications
Volume57
Issue number15
Early online date19 Jan 2021
DOIs
Publication statusPublished - 23 Feb 2021

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