Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

Karen J Taylor; Andrew Sims; Liang Liang; Dana Faratian; Morwenna Muir; Graeme Walker; Barbara Kuske; Mike Dixon; David A Cameron; David J Harrison; Simon P Langdon

doi:10.1186/bcr2593

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

Karen J Taylor, Andrew Sims, Liang Liang, Dana Faratian, Morwenna Muir, Graeme Walker, Barbara Kuske, Mike Dixon, David A Cameron, David J Harrison, Simon P Langdon

Research output: Contribution to journal › Article › peer-review

Abstract

Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner.

Original language	English
Article number	R39
Journal	Breast Cancer Research
Volume	12
Issue number	3
DOIs	https://doi.org/10.1186/bcr2593
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Animals
Antineoplastic Combined Chemotherapy Protocols
Blotting, Western
Breast Neoplasms
Drug Resistance, Neoplasm
Estradiol
Estrogen Antagonists
Estrogens
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Nude
Oligonucleotide Array Sequence Analysis
Prognosis
RNA, Messenger
Receptors, Estrogen
Reverse Transcriptase Polymerase Chain Reaction
Tamoxifen
Tumor Markers, Biological
Xenograft Model Antitumor Assays

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10.1186/bcr2593

Taylor KJ et al 2010Submitted manuscript, 2.01 MB

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@article{7144da1b87d6437aad324de63b7af735,

title = "Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer",

abstract = "Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner.",

keywords = "Animals, Antineoplastic Combined Chemotherapy Protocols, Blotting, Western, Breast Neoplasms, Drug Resistance, Neoplasm, Estradiol, Estrogen Antagonists, Estrogens, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Nude, Oligonucleotide Array Sequence Analysis, Prognosis, RNA, Messenger, Receptors, Estrogen, Reverse Transcriptase Polymerase Chain Reaction, Tamoxifen, Tumor Markers, Biological, Xenograft Model Antitumor Assays",

author = "Taylor, {Karen J} and Andrew Sims and Liang Liang and Dana Faratian and Morwenna Muir and Graeme Walker and Barbara Kuske and Mike Dixon and Cameron, {David A} and Harrison, {David J} and Langdon, {Simon P}",

year = "2010",

doi = "10.1186/bcr2593",

language = "English",

volume = "12",

journal = "Breast Cancer Research",

issn = "1465-542X",

publisher = "BioMed Central",

number = "3",

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TY - JOUR

T1 - Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

AU - Taylor, Karen J

AU - Sims, Andrew

AU - Liang, Liang

AU - Faratian, Dana

AU - Muir, Morwenna

AU - Walker, Graeme

AU - Kuske, Barbara

AU - Dixon, Mike

AU - Cameron, David A

AU - Harrison, David J

AU - Langdon, Simon P

PY - 2010

Y1 - 2010

N2 - Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner.

AB - Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner.

KW - Animals

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Blotting, Western

KW - Breast Neoplasms

KW - Drug Resistance, Neoplasm

KW - Estradiol

KW - Estrogen Antagonists

KW - Estrogens

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mice

KW - Mice, Nude

KW - Oligonucleotide Array Sequence Analysis

KW - Prognosis

KW - RNA, Messenger

KW - Receptors, Estrogen

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Tamoxifen

KW - Tumor Markers, Biological

KW - Xenograft Model Antitumor Assays

UR - http://www.scopus.com/inward/record.url?scp=78149490372&partnerID=8YFLogxK

U2 - 10.1186/bcr2593

DO - 10.1186/bcr2593

M3 - Article

C2 - 20569502

SN - 1465-542X

VL - 12

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 3

M1 - R39

ER -

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

Abstract

Keywords / Materials (for Non-textual outputs)

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