Abstract / Description of output
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments.
Original language | English |
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Article number | e1002125 |
Number of pages | 19 |
Journal | PLoS Biology |
Volume | 13 |
Issue number | 4 |
Early online date | 17 Apr 2015 |
DOIs | |
Publication status | Published - 17 Apr 2015 |
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Miguel O. Bernabeu
- Deanery of Molecular, Genetic and Population Health Sciences - Personal Chair in Computational Medicine
- Centre for Medical Informatics
- Usher Institute
Person: Academic: Research Active