E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro

D W Owens; V G Brunton; E K Parkinson; M C Frame

doi:10.1006/bbrc.2000.2292

E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro

D W Owens, V G Brunton, E K Parkinson, M C Frame

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.

Original language	English
Pages (from-to)	369-76
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	269
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.2000.2292
Publication status	Published - 16 Mar 2000

Keywords / Materials (for Non-textual outputs)

Cadherins
Calcium
Cell Adhesion
Cell Communication
Cell Differentiation
Cells, Cultured
Humans
Keratinocytes
Protein Precursors
Transglutaminases

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10.1006/bbrc.2000.2292

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title = "E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro",

abstract = "The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.",

keywords = "Cadherins, Calcium, Cell Adhesion, Cell Communication, Cell Differentiation, Cells, Cultured, Humans, Keratinocytes, Protein Precursors, Transglutaminases",

author = "Owens, {D W} and Brunton, {V G} and Parkinson, {E K} and Frame, {M C}",

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AU - Owens, D W

AU - Brunton, V G

AU - Parkinson, E K

AU - Frame, M C

PY - 2000/3/16

Y1 - 2000/3/16

N2 - The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.

AB - The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.

KW - Cadherins

KW - Calcium

KW - Cell Adhesion

KW - Cell Communication

KW - Cell Differentiation

KW - Cells, Cultured

KW - Humans

KW - Keratinocytes

KW - Protein Precursors

KW - Transglutaminases

U2 - 10.1006/bbrc.2000.2292

DO - 10.1006/bbrc.2000.2292

M3 - Article

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SN - 0006-291X

VL - 269

SP - 369

EP - 376

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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