Early and non-reversible decrease of CD161++/MAIT cells in HIV infection

Cormac Cosgrove, James E Ussher, Andri Rauch, Kathleen Gartner, Ayako Kurioka, Michael H. Huhn, Krista Adelmann, Yu-Hoi Kang, Joannah R Fergusson, Peter Simmonds, Philip Goulder, Ted H Hansen, J. Fox, HF Gunthard, Nina Khanna, Fiona Powrie, Alan Steel, Brian Gazzard, Rodney E Phillips, John FraterHolm Uhlig, Paul Klenerman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++CD8+T-cells are a tissue-infiltrating population that produce IL17A, IL22, IFNγ and TNFα, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR Vα7.2, the canonical feature of Mucosal Associated Invariant T-cells (MAIT) and have been recently implicated in host defence against pathogens. We analyzed the frequency and function of CD161++/MAIT-cells in peripheral blood and tissue from patients with early-stage or chronic-stage HIV infection. We show that the CD161++/MAIT-cell population is significantly decreased in early HIV infection and fails to recover despite otherwise successful treatment. We provide evidence that CD161++/MAIT-cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact on mucosal defence and could be important in susceptibility to specific opportunistic infections in HIV.
Original languageEnglish
Pages (from-to)951-61
Number of pages11
JournalBlood
Volume121
Issue number6
Early online date18 Dec 2012
DOIs
Publication statusPublished - 7 Feb 2013

Keywords / Materials (for Non-textual outputs)

  • HIV Infections

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  • Infection of CD8 lymphocytes by HIV -1

    Simmonds, P.

    MRC

    17/02/0930/04/12

    Project: Research

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