Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies

INTERACT Investigators; Edward Chan; Craig S Anderson; Xia Wang; Hisatomi Arima; Anubhav Saxena; Tom J Moullaali; Candice Delcourt; Guojun Wu; Jinchao Wang; Guofang Chen; Pablo M Lavados; Christian Stapf; Thompson Robinson; John Chalmers

doi:10.1159/000448897

Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies

INTERACT Investigators, Edward Chan, Craig S Anderson, Xia Wang, Hisatomi Arima, Anubhav Saxena, Tom J Moullaali, Candice Delcourt, Guojun Wu, Jinchao Wang, Guofang Chen, Pablo M Lavados, Christian Stapf, Thompson Robinson, John Chalmers

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Abstract

BACKGROUND: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis.

AIM: To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth.

METHODS: Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance.

RESULTS: There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26).

CONCLUSIONS: Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.

Original language	English
Pages (from-to)	71-75
Number of pages	5
Journal	Cerebrovascular diseases extra
Volume	6
Issue number	3
DOIs	https://doi.org/10.1159/000448897
Publication status	Published - 8 Sept 2016

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10.1159/000448897

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INTERACT Investigators, Chan, E., Anderson, C. S., Wang, X., Arima, H., Saxena, A., Moullaali, T. J., Delcourt, C., Wu, G., Wang, J., Chen, G., Lavados, P. M., Stapf, C., Robinson, T., & Chalmers, J. (2016). Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies. Cerebrovascular diseases extra, 6(3), 71-75. https://doi.org/10.1159/000448897

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title = "Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies",

abstract = "BACKGROUND: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis.AIM: To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth.METHODS: Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance.RESULTS: There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26).CONCLUSIONS: Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.",

keywords = "Journal Article",

author = "{INTERACT Investigators} and Edward Chan and Anderson, {Craig S} and Xia Wang and Hisatomi Arima and Anubhav Saxena and Moullaali, {Tom J} and Candice Delcourt and Guojun Wu and Jinchao Wang and Guofang Chen and Lavados, {Pablo M} and Christian Stapf and Thompson Robinson and John Chalmers",

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year = "2016",

month = sep,

day = "8",

doi = "10.1159/000448897",

language = "English",

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INTERACT Investigators, Chan, E, Anderson, CS, Wang, X, Arima, H, Saxena, A, Moullaali, TJ, Delcourt, C, Wu, G, Wang, J, Chen, G, Lavados, PM, Stapf, C, Robinson, T & Chalmers, J 2016, 'Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies', Cerebrovascular diseases extra, vol. 6, no. 3, pp. 71-75. https://doi.org/10.1159/000448897

TY - JOUR

T1 - Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage

T2 - Results of the INTERACT Studies

AU - INTERACT Investigators

AU - Chan, Edward

AU - Anderson, Craig S

AU - Wang, Xia

AU - Arima, Hisatomi

AU - Saxena, Anubhav

AU - Moullaali, Tom J

AU - Delcourt, Candice

AU - Wu, Guojun

AU - Wang, Jinchao

AU - Chen, Guofang

AU - Lavados, Pablo M

AU - Stapf, Christian

AU - Robinson, Thompson

AU - Chalmers, John

PY - 2016/9/8

Y1 - 2016/9/8

N2 - BACKGROUND: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis.AIM: To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth.METHODS: Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance.RESULTS: There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26).CONCLUSIONS: Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.

AB - BACKGROUND: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis.AIM: To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth.METHODS: Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance.RESULTS: There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26).CONCLUSIONS: Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.

KW - Journal Article

U2 - 10.1159/000448897

DO - 10.1159/000448897

M3 - Article

C2 - 27603933

SN - 1664-5456

VL - 6

SP - 71

EP - 75

JO - Cerebrovascular diseases extra

JF - Cerebrovascular diseases extra

IS - 3

ER -

Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies

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