@article{3f3f4bb3aa544c658a83603830daf314,
title = "Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age",
abstract = "Inflammation is implicated in depression and psychosis, including association of childhood inflammatory markers on the subsequent risk of developing symptoms. However, it is unknown whether early-life inflammatory markers are associated with the number of depressive and psychotic symptoms from childhood to adulthood. Using the prospective Avon Longitudinal Study of Children and Parents birth cohort (N = up-to 6401), we have examined longitudinal associations of early-life inflammation [exposures: interleukin-6 (IL-6), C-reactive protein (CRP) levels at age 9y; IL-6 and CRP DNA-methylation (DNAm) scores at birth and age 7y; and IL-6 and CRP polygenic risk scores (PRSs)] with the number of depressive episodes and psychotic experiences (PEs) between ages 10-28 years. Psychiatric outcomes were assessed using the Short Mood and Feelings Questionnaire and Psychotic Like Symptoms Questionnaires, respectively. Exposure-outcome associations were tested using negative binomial models, which were adjusted for metabolic and sociodemographic factors. Serum IL-6 levels at age 9y were associated with the total number of depressive episodes between 10 and 28y in the base model (n = 4835; β = 0.066; 95%CI:0.020-0.113; pFDR = 0.041) which was weaker when adjusting for metabolic and sociodemographic factors. Weak associations were observed between inflammatory markers (serum IL-6 and CRP DNAm scores) and total number of PEs. Other inflammatory markers were not associated with depression or PEs. Early-life inflammatory markers are associated with the burden of depressive episodes and of PEs subsequently from childhood to adulthood. These findings support a potential role of early-life inflammation in the aetiology of depression and psychosis and highlight inflammation as a potential target for treatment and prevention.",
keywords = "ALSPAC, Depression, Inflammation, Life course, Omics, Psychotic experiences",
author = "Edmondson-Stait, {Amelia J.} and Xueyi Shen and Adams, {Mark J.} and Barbu, {Miruna C.} and Jones, {Hannah J.} and Miron, {Veronique E.} and Judith Allardyce and Boardman, {James P.} and Lawrie, {Stephen M.} and McIntosh, {Andrew M.} and Khandaker, {Golam M.} and Kwong, {Alex S.F.} and Whalley, {Heather C.}",
note = "Funding Information: The UK Medical Research Council and Wellcome (Grant No.: 217065/Z/19/Z ) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Amelia Edmondson-Stait and Alex Kwong will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website. Funding Information: This research was funded in whole, or in part, by the Wellcome Trust (Grant No. 108890/Z/15/Z). For the purpose of open access, the authors have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. The UK Medical Research Council and Wellcome (Grant No.: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Amelia Edmondson-Stait and Alex Kwong will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website. (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf); This research was specifically funded by the MRC (MR/M006727/1 and GO701503/85179), Wellcome Trust (08426812/Z/07/Z) ], Wellcome Trust and MRC (092731), NIH (PD301198-SC101645). We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. MCB is supported by a Guarantors of Brain Non-clinical Post-Doctoral Fellowship. HJJ is supported by the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. JA acknowledges a personal fellowship from the Wellcome Trust (209176/A/17/Z). AMM acknowledges funding support from the Wellcome Trust Innovator Award (Grant No. 220857/Z/20/Z). GMK acknowledges funding support from the Wellcome Trust (Grant No. 201486/Z/16/Z), the Medical Research Council (Grant No. MC_PC_17213, Grant No. MR/S037675/1, and Grant No. MR/W014416/1), The MQ: Transforming Mental Health (Grant No. MQDS17/40), and the BMA Foundation (J. Moulton Grant 2019). Funding Information: MCB is supported by a Guarantors of Brain Non-clinical Post-Doctoral Fellowship . HJJ is supported by the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. JA acknowledges a personal fellowship from the Wellcome Trust (209176/A/17/Z). AMM acknowledges funding support from the Wellcome Trust Innovator Award (Grant No. 220857/Z/20/Z ). GMK acknowledges funding support from the Wellcome Trust (Grant No. 201486/Z/16/Z ), the Medical Research Council (Grant No. MC_PC_17213 , Grant No. MR/S037675/1 , and Grant No. MR/W014416/1 ), The MQ: Transforming Mental Health (Grant No. MQDS17/40 ), and the BMA Foundation (J. Moulton Grant 2019). Funding Information: ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ); This research was specifically funded by the MRC ( MR/M006727/1 and GO701503/85179 ), Wellcome Trust ( 08426812/Z/07/Z ) ], Wellcome Trust and MRC ( 092731 ), NIH ( PD301198-SC101645 ). Funding Information: This research was funded in whole, or in part, by the Wellcome Trust (Grant No. 108890/Z/15/Z ). For the purpose of open access, the authors have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = dec,
doi = "10.1016/j.bbih.2022.100528",
language = "English",
volume = "26",
journal = "Brain, Behavior, & Immunity - Health",
issn = "2666-3546",
publisher = "Elsevier",
}