Early risk factors for miscarriage: a prospective cohort study in pregnant women.

P. C. Arck, M. Rücke, M. Rose, J. Szekeres-Bartho, A. J. Douglas, M. Pritsch, S. Blois, M. K. Pincus, N. Bärenstrauch, J. W. Dudenhausen, K. Nakamura, S. Sheps, B. F. Klapp

Research output: Contribution to journalArticlepeer-review


Many pregnancies are lost during early gestation, but clinicians still lack tools to recognize risk factors for miscarriage. Thus, the identification of risk factors for miscarriage during the first trimester in women with no obvious risk for a pregnancy loss was the aim of this prospective cohort trial. A total of 1098 women between gestation weeks 4 and 12 in whom. no apparent signs of a threatened pregnancy could be diagnosed were recruited. Demographic, anamnestic, psychometric and biological data were documented at recruitment and pregnancy outcomes were registered subsequently. Among the cases with sufficiently available data, 809 successfully progressing pregnancies and 5.5 subsequent miscarriages were reported. In this cohort, risk of miscarriage was significantly increased in women at higher age (>33 years), lower body mass index (
Original languageEnglish
Pages (from-to)101-113
Number of pages13
JournalReproductive BioMedicine Online
Issue number1
Publication statusPublished - Jul 2008


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