Earth-Abundant Metal Catalysis Enabled by Counterion Activation

Riaz Agahi, Amy J. Challinor, Neil B. Carter, Stephen P. Thomas

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A pre-catalyst activation strategy has been developed for Earth-abundant metal catalysis enabled by counterion dissociation and demonstrated through alkene hydroboration. Commercially available iron- and cobalt tetrafluoroborate salts were found to catalyze the hydroboration of aryl- and alkyl alkenes with good functional group tolerance (Fe, 12 substrates; Co, 13 substrates) with 3 structurally distinct ligands. Key to this endogenous activation was counterion dissociation to generate fluoride which indirectly activates the pre-catalyst by reaction with pinacol borane.
Original languageEnglish
JournalOrganic letters
Early online date4 Feb 2019
DOIs
Publication statusE-pub ahead of print - 4 Feb 2019

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