TY - JOUR
T1 - ECM-based materials in cardiovascular applications
T2 - Inherent healing potential and augmentation of native regenerative processes
AU - Piterina, Anna V
AU - Cloonan, Aidan J
AU - Meaney, Claire L
AU - Davis, Laura M
AU - Callanan, Anthony
AU - Walsh, Michael T
AU - McGloughlin, Tim M
PY - 2009
Y1 - 2009
N2 - The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.
AB - The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.
U2 - 10.3390/ijms10104375
DO - 10.3390/ijms10104375
M3 - Article
C2 - 20057951
SN - 1422-0067
VL - 10
SP - 4375
EP - 4417
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 10
ER -