Ecological and evolutionary dynamics of multi-strain RNA viruses

Dennis N.  Makau; Samantha Lycett; Matthew  Michalska-Smith; Igor A D Paploski; Maxim C-J Cheeran; Meggan E. Craft; Rowland Kao; Declan C.  Schroeder; Andrea Wilson; Kimberly VanderWaal

doi:10.1038/s41559-022-01860-6

Ecological and evolutionary dynamics of multi-strain RNA viruses

Dennis N. Makau, Samantha Lycett, Matthew Michalska-Smith, Igor A D Paploski, Maxim C-J Cheeran, Meggan E. Craft, Rowland Kao, Declan C. Schroeder , Andrea Wilson, Kimberly VanderWaal^*

^*Corresponding author for this work

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Potential interactions amongst co-circulating viral strains in host populations are often overlooked in the study of virus transmission. However, these interactions likely shape transmission dynamics by influencing host immune responses or altering the relative fitness amongst co-circulating strains. In this Review, we describe multi-strain dynamics from ecological and evolutionary perspectives, outline scales in which multi-strain dynamics occur, and summarize important immunological, phylogenetic, and mathematical modeling approaches used to quantify interactions amongst strains. We also discuss how host-pathogen interactions influence the co-circulation of pathogens. Finally, we highlight outstanding questions and knowledge gaps in the current theory and study of ecological and evolutionary dynamics of multi strain viruses.

Original language	English
Pages (from-to)	1414-1422
Journal	Nature Ecology & Evolution
Volume	6
Early online date	22 Sept 2022
DOIs	https://doi.org/10.1038/s41559-022-01860-6
Publication status	Published - 1 Oct 2022

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10.1038/s41559-022-01860-6

2022-07-22_Makau_Multistrain_review_accepted_with_figsAccepted author manuscript, 3.57 MBLicence: Creative Commons: Attribution (CC-BY)

Drivers of diversity and transmission of co-circulating viral lineages in host meta-populations
Lycett, S., Kao, R. & Wilson, A.
BBSRC
1/09/19 → 31/08/23
Project: Research

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title = "Ecological and evolutionary dynamics of multi-strain RNA viruses",

abstract = "Potential interactions amongst co-circulating viral strains in host populations are often overlooked in the study of virus transmission. However, these interactions likely shape transmission dynamics by influencing host immune responses or altering the relative fitness amongst co-circulating strains. In this Review, we describe multi-strain dynamics from ecological and evolutionary perspectives, outline scales in which multi-strain dynamics occur, and summarize important immunological, phylogenetic, and mathematical modeling approaches used to quantify interactions amongst strains. We also discuss how host-pathogen interactions influence the co-circulation of pathogens. Finally, we highlight outstanding questions and knowledge gaps in the current theory and study of ecological and evolutionary dynamics of multi strain viruses.",

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doi = "10.1038/s41559-022-01860-6",

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AU - Makau, Dennis N.

AU - Lycett, Samantha

AU - Michalska-Smith, Matthew

AU - Paploski, Igor A D

AU - Cheeran, Maxim C-J

AU - Craft, Meggan E.

AU - Kao, Rowland

AU - Schroeder , Declan C.

AU - Wilson, Andrea

AU - VanderWaal, Kimberly

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Potential interactions amongst co-circulating viral strains in host populations are often overlooked in the study of virus transmission. However, these interactions likely shape transmission dynamics by influencing host immune responses or altering the relative fitness amongst co-circulating strains. In this Review, we describe multi-strain dynamics from ecological and evolutionary perspectives, outline scales in which multi-strain dynamics occur, and summarize important immunological, phylogenetic, and mathematical modeling approaches used to quantify interactions amongst strains. We also discuss how host-pathogen interactions influence the co-circulation of pathogens. Finally, we highlight outstanding questions and knowledge gaps in the current theory and study of ecological and evolutionary dynamics of multi strain viruses.

AB - Potential interactions amongst co-circulating viral strains in host populations are often overlooked in the study of virus transmission. However, these interactions likely shape transmission dynamics by influencing host immune responses or altering the relative fitness amongst co-circulating strains. In this Review, we describe multi-strain dynamics from ecological and evolutionary perspectives, outline scales in which multi-strain dynamics occur, and summarize important immunological, phylogenetic, and mathematical modeling approaches used to quantify interactions amongst strains. We also discuss how host-pathogen interactions influence the co-circulation of pathogens. Finally, we highlight outstanding questions and knowledge gaps in the current theory and study of ecological and evolutionary dynamics of multi strain viruses.

U2 - 10.1038/s41559-022-01860-6

DO - 10.1038/s41559-022-01860-6

M3 - Article

SN - 2397-334X

VL - 6

SP - 1414

EP - 1422

JO - Nature Ecology & Evolution

JF - Nature Ecology & Evolution

ER -

Ecological and evolutionary dynamics of multi-strain RNA viruses

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Drivers of diversity and transmission of co-circulating viral lineages in host meta-populations

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