Editorial: The Immunomodulatory Properties of Extracellular Vesicles From Pathogens, Immune Cells, and Non-immune Cells

Ivan K. H. Poon, Christopher D. Gregory, Maria Kaparakis-liaskos

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Intercellular communication is key for immune regulation and extracellular vesicles (EVs) are emerging as important mediators of this process. EVs like exosomes, microvesicles, and apoptotic bodies are membrane-bound vesicles that can be released by both immune and non-immune cells. Although different types of EVs vary greatly in their size (~30 nm to 5μm in diameter) and mechanism of formation, it is now well-established that the cellular constituents in/on EVs (e.g., antigens, cytokines, membrane proteins, and microRNAs) can regulate a variety of immune responses. Besides mammalian cells, bacteria, fungi, and parasites can also release membrane vesicles tomodulate host immune responses. In this research topic, a collection of primary research and review papers explored the immunoregulatory properties of EVs released from immune cells, tumor cells, apoptotic cells as well as pathogens.

Original languageEnglish
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 19 Dec 2018

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