TY - JOUR
T1 - Effect of a female community health volunteer-delivered intervention to increase cervical cancer screening uptake in Nepal
T2 - a cluster randomized controlled trial
AU - Dhoj Shrestha, Aamod
AU - Gyawali, Bishal
AU - Shrestha, Archana
AU - Shrestha, Sadeep
AU - Neupane, Dinesh
AU - Ghimire, Sarita
AU - Campbell, Christine
AU - Kallestrup, Per
N1 - Funding Information:
We would like to thank the FCHVs, study participants, and the Nepal Development Society, team. We would like to acknowledge the data safety and monitoring board members Prof. Dr. Bhagwan Koirala, Prof. Dr. Stephen Hodgins, Prof. Dr. Kedar Baral, Mr. Claus Høstrup Vestergaard, and Prof. Dr. Lochana Shrestha. We particularly thank Abhishek Spakota, Amrita Thapa, Garima Neupane, Sabina Timilsina, Sneha Sharma, Sonam Magar, Tara Ballav Adhikari, Pabitra Babu Soti, and Hari Prasad Pokhrel for their valuable support and contribution in conducting this study. This study is part of research work toward a PhD degree at Aarhus University, Denmark (https://phd.health.au.dk/), and is funded by a university scholarship (Project number: 10439) awarded to ADS. The funding organizations do not have any role in the study design, the data collection, analysis, interpretation, or the reporting of the results.
Funding Information:
We would like to thank the FCHVs, study participants, and the Nepal Development Society, team. We would like to acknowledge the data safety and monitoring board members Prof. Dr. Bhagwan Koirala, Prof. Dr. Stephen Hodgins, Prof. Dr. Kedar Baral, Mr. Claus Høstrup Vestergaard, and Prof. Dr. Lochana Shrestha. We particularly thank Abhishek Spakota, Amrita Thapa, Garima Neupane, Sabina Timilsina, Sneha Sharma, Sonam Magar, Tara Ballav Adhikari, Pabitra Babu Soti, and Hari Prasad Pokhrel for their valuable support and contribution in conducting this study. This study is part of research work toward a PhD degree at Aarhus University, Denmark ( https://phd.health.au.dk/ ), and is funded by a university scholarship (Project number: 10439) awarded to ADS. The funding organizations do not have any role in the study design, the data collection, analysis, interpretation, or the reporting of the results.
Publisher Copyright:
© 2022
PY - 2022/10/1
Y1 - 2022/10/1
N2 - This study aimed to assess the effect of Female Community Health Volunteer (FCHV)-delivered intervention to increase cervical cancer screening uptake among Nepalese women. A community-based, open-label, 2-group, cluster randomized controlled trial (CRCT) was conducted in a semi-urban setting in Western Nepal. Fourteen clusters (1:1) were randomly assigned to the intervention group, which received a 12-month intervention delivered by FCHVs or the control group (usual care). Between April and June 2019, 690 women aged 30-60 years were recruited for CRCT during the baseline survey. A follow-up assessment was conducted after the completion of the 12 months intervention. The primary outcome was the change in cervical cancer screening from baseline to 12-month follow-up. Of 690 women, 646 women completed the trial. 254 women in the intervention group and 385 women in the control group were included in the primary outcome analysis. There was a significant increase in cervical cancer screening uptake in the intervention group [relative risk (RR), 1.48; 95 % confidence interval (CI) 1.32, 1.66; P < 0.01)], compared to the control group. The secondary outcome was the change in median knowledge score among women that increased from 2 [interquartile range (IQR) 1-4] (baseline) to 6 [IQR 3-9] (follow-up) in the intervention group. However, the median knowledge score remained almost the same among women in the control group 2 [IQR 1-5] to 3 [IQR 2-5]. Our study findings reported that an FCHV-delivered intervention significantly increased cervical cancer screening uptake among women living in a semi-urban setting in Nepal. Trial registration: ClinicalTrials.gov NCT03808064.
AB - This study aimed to assess the effect of Female Community Health Volunteer (FCHV)-delivered intervention to increase cervical cancer screening uptake among Nepalese women. A community-based, open-label, 2-group, cluster randomized controlled trial (CRCT) was conducted in a semi-urban setting in Western Nepal. Fourteen clusters (1:1) were randomly assigned to the intervention group, which received a 12-month intervention delivered by FCHVs or the control group (usual care). Between April and June 2019, 690 women aged 30-60 years were recruited for CRCT during the baseline survey. A follow-up assessment was conducted after the completion of the 12 months intervention. The primary outcome was the change in cervical cancer screening from baseline to 12-month follow-up. Of 690 women, 646 women completed the trial. 254 women in the intervention group and 385 women in the control group were included in the primary outcome analysis. There was a significant increase in cervical cancer screening uptake in the intervention group [relative risk (RR), 1.48; 95 % confidence interval (CI) 1.32, 1.66; P < 0.01)], compared to the control group. The secondary outcome was the change in median knowledge score among women that increased from 2 [interquartile range (IQR) 1-4] (baseline) to 6 [IQR 3-9] (follow-up) in the intervention group. However, the median knowledge score remained almost the same among women in the control group 2 [IQR 1-5] to 3 [IQR 2-5]. Our study findings reported that an FCHV-delivered intervention significantly increased cervical cancer screening uptake among women living in a semi-urban setting in Nepal. Trial registration: ClinicalTrials.gov NCT03808064.
KW - Cervical cancer screening
KW - Cluster randomized controlled trial
KW - Community-based intervention
KW - Female Community Health Volunteer
KW - Nepal
U2 - 10.1016/j.pmedr.2022.101948
DO - 10.1016/j.pmedr.2022.101948
M3 - Article
C2 - 36161136
SN - 2211-3355
VL - 29
SP - 101948
JO - Preventive Medicine Reports
JF - Preventive Medicine Reports
M1 - 101948
ER -