Effect of alpha lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance

Andrea M McNeilly, Gareth W Davison, Marie H Murphy, Nida Nadeem, Tom Trinick, Ellie Duly, Anna Novials, Jane McEneny

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Obese subjects with impaired glucose tolerance (IGT) are more susceptible than healthy individuals to oxidativestress and cardiovascular disease. This randomised controlled investigation was designed to test the hypothesisthat a-lipoic acid supplementation and exercise training may elicit favourable clinical changes in obese subjectswith IGT. All data were collected from 24 obese (BMI ≥ 30 kg/m2) IGT patients. Following participant randomisationinto two groups, fasting venous blood samples were obtained at baseline, and before and following intervention.The first group consisted of 12 participants who completed a 12 week control phase followed by 12 weeks ofchronic exercise at 65% HRmax for 30 minutes a day, 5 days per week, while ingesting 1 gram per day of a-lipoicacid for 12 weeks. The second group consisted of 12 participants who completed the same 12 week control phase,but this was followed by 12 weeks of 1 gram per day of a-lipoic acid supplementation only (no exercise). Themain findings show a comparatively greater rate of low density lipoprotein (LDL) oxidation in the group consistingof a-lipoic acid only (p
Original languageEnglish
Pages (from-to)217-226
Number of pages10
JournalLipids in Health and Disease
Volume10
Issue number1
DOIs
Publication statusPublished - 22 Nov 2011

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