Abstract / Description of output
Obese subjects with impaired glucose tolerance (IGT) are more susceptible than healthy individuals to oxidativestress and cardiovascular disease. This randomised controlled investigation was designed to test the hypothesisthat a-lipoic acid supplementation and exercise training may elicit favourable clinical changes in obese subjectswith IGT. All data were collected from 24 obese (BMI ≥ 30 kg/m2) IGT patients. Following participant randomisationinto two groups, fasting venous blood samples were obtained at baseline, and before and following intervention.The first group consisted of 12 participants who completed a 12 week control phase followed by 12 weeks ofchronic exercise at 65% HRmax for 30 minutes a day, 5 days per week, while ingesting 1 gram per day of a-lipoicacid for 12 weeks. The second group consisted of 12 participants who completed the same 12 week control phase,but this was followed by 12 weeks of 1 gram per day of a-lipoic acid supplementation only (no exercise). Themain findings show a comparatively greater rate of low density lipoprotein (LDL) oxidation in the group consistingof a-lipoic acid only (p
Original language | English |
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Pages (from-to) | 217-226 |
Number of pages | 10 |
Journal | Lipids in Health and Disease |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 22 Nov 2011 |