Effect of anaemia and erythrocyte indices on canine glycated haemoglobin

Ioannis Oikonomidis, Theodora Tsouloufi, Nektarios Soubasis, Maria Kritsepi-Konstantinou

Research output: Contribution to journalArticlepeer-review


Background HbA1c depends on blood glucose concentration and erythrocyte lifespan, and. consequently, erythrocyte indices may affect HbA1c; our objective was to study this effect in dogs. Methods Blood samples from two (healthy and anaemic) age- and sex-matched, normoglycaemic populations were prospectively included. Advia 120 and Capillarys 2 flex-piercing were used for the haematological and HbA1c analyses, respectively. Results Lower mean HbA1c was found in dogs with regenerative (n=8, 0.88±0.58%) and non-regenerative anaemia (n=12, 1.36±0.56%) compared to healthy ones (n=40, 1.68±0.48%); the difference was significant (P<0.001) between the healthy dogs and those with regenerative anaemia. HbA1c was significantly correlated (P<0.05) with red blood cell count (r=0.506), haemoglobin (r=0.474), haematocrit (r=0.467), mean corpuscular volume (r=-0.289), mean corpuscular haemoglobin concentration (r=0.284), red cell distribution width (r=-0.286) and reticulocytes (rs=-0.542). Conclusion Anaemia, particularly if regenerative, can lower HbA1c. The significant correlation between HbA1c and erythrocyte indices likely reflects the effect of erythrocyte turnover on HbA1c.
Original languageEnglish
JournalVeterinary Record
Publication statusPublished - 26 Apr 2021


  • Anaemia
  • Diabetes mellitus
  • Dog
  • ;Haematology
  • HbA1c
  • Hyperglycaemia


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