Background HbA1c depends on blood glucose concentration and erythrocyte lifespan, and. consequently, erythrocyte indices may affect HbA1c; our objective was to study this effect in dogs. Methods Blood samples from two (healthy and anaemic) age- and sex-matched, normoglycaemic populations were prospectively included. Advia 120 and Capillarys 2 flex-piercing were used for the haematological and HbA1c analyses, respectively. Results Lower mean HbA1c was found in dogs with regenerative (n=8, 0.88±0.58%) and non-regenerative anaemia (n=12, 1.36±0.56%) compared to healthy ones (n=40, 1.68±0.48%); the difference was significant (P<0.001) between the healthy dogs and those with regenerative anaemia. HbA1c was significantly correlated (P<0.05) with red blood cell count (r=0.506), haemoglobin (r=0.474), haematocrit (r=0.467), mean corpuscular volume (r=-0.289), mean corpuscular haemoglobin concentration (r=0.284), red cell distribution width (r=-0.286) and reticulocytes (rs=-0.542). Conclusion Anaemia, particularly if regenerative, can lower HbA1c. The significant correlation between HbA1c and erythrocyte indices likely reflects the effect of erythrocyte turnover on HbA1c.
- Diabetes mellitus