Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

MO McCarron*, CJ Weir, KW Muir, KL Hoffmann, C Graffagnino, JAR Nicoll, KR Lees, MJ Alberts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalActa Neurologica Scandinavica
Volume107
Issue number2
Publication statusPublished - Feb 2003

Keywords

  • intracerebral haemorrhage
  • apolipoprotein E
  • survival
  • outcome
  • E POLYMORPHISM
  • CEREBROVASCULAR-DISEASE
  • HEMORRHAGE
  • ASSOCIATION
  • SURVIVAL
  • STROKE
  • ALLELE
  • DEATH

Fingerprint

Dive into the research topics of 'Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage'. Together they form a unique fingerprint.

Cite this