Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

MO McCarron; CJ Weir; KW Muir; KL Hoffmann; C Graffagnino; JAR Nicoll; KR Lees; MJ Alberts

Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

MO McCarron^*, CJ Weir, KW Muir, KL Hoffmann, C Graffagnino, JAR Nicoll, KR Lees, MJ Alberts

^*Corresponding author for this work

School of Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.

Original language	English
Pages (from-to)	106-109
Number of pages	4
Journal	Acta Neurologica Scandinavica
Volume	107
Issue number	2
Publication status	Published - Feb 2003

Keywords / Materials (for Non-textual outputs)

intracerebral haemorrhage
apolipoprotein E
survival
outcome
E POLYMORPHISM
CEREBROVASCULAR-DISEASE
HEMORRHAGE
ASSOCIATION
SURVIVAL
STROKE
ALLELE
DEATH

Cite this

@article{0e92f23f5cb04aed88d9889cc7c6d644,

title = "Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage",

abstract = "Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30\%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.",

keywords = "intracerebral haemorrhage, apolipoprotein E, survival, outcome, E POLYMORPHISM, CEREBROVASCULAR-DISEASE, HEMORRHAGE, ASSOCIATION, SURVIVAL, STROKE, ALLELE, DEATH",

author = "MO McCarron and CJ Weir and KW Muir and KL Hoffmann and C Graffagnino and JAR Nicoll and KR Lees and MJ Alberts",

year = "2003",

month = feb,

language = "English",

volume = "107",

pages = "106--109",

journal = "Acta Neurologica Scandinavica",

issn = "0001-6314",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

AU - McCarron, MO

AU - Weir, CJ

AU - Muir, KW

AU - Hoffmann, KL

AU - Graffagnino, C

AU - Nicoll, JAR

AU - Lees, KR

AU - Alberts, MJ

PY - 2003/2

Y1 - 2003/2

N2 - Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.

AB - Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.

KW - intracerebral haemorrhage

KW - apolipoprotein E

KW - survival

KW - outcome

KW - E POLYMORPHISM

KW - CEREBROVASCULAR-DISEASE

KW - HEMORRHAGE

KW - ASSOCIATION

KW - SURVIVAL

KW - STROKE

KW - ALLELE

KW - DEATH

M3 - Article

SN - 0001-6314

VL - 107

SP - 106

EP - 109

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 2

ER -

Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

Abstract

Keywords / Materials (for Non-textual outputs)

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