Effect of bivalent HPV immunisation on cytological and histological findings at second and subsequent screens a longitudinal study

Timothy Palmer, K.G. Pollock, Kate Cuschieri, A West, C Robertson, M Cruickshank, K. Kavanagh

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Background / Objectives
Scotland implemented school-based routine hr-HPV immunisation with Cervarix® at age 12/13 for women born in and after 1995, with catch-up immunisation for women born between 1990 and 1995. Women in the catch-up cohort have been screened since 2010, and routinely immunised women since 2015. As eight years have elapsed since the first immunised women began screening, it is possible to document the effect of HPV immunisation at the second and subsequent screening rounds for women in the catch-up cohort. This will be the first longitudinal data on the effect of bivalent HPV immunisation with direct linkage between immunisation and disease outcome
Results
Data on all cytology results and histology results, together with the number of doses of vaccine received, were extracted from the Scottish National Screening database for all women born between 1 January 1988 and 6 June 1996. Women born in 1988-1990 are largely un-immunised, women born in 1991-1994 are the catch-up cohort, and those born in 1995 and 1996 are the routinely immunised cohort. The reporting rates of cytological abnormalities and the histologically confirmed disease rates are compared between immunised and non-immunised women at their second and subsequent attendance for screening.284/490
Conclusion
A total of 409,847 women were identified within the age range. A total of 127,855 women have had more than one cytology result recorded of whom 94,854 had negative cytology at their first screen. The cytology results and histological diagnoses taken from these women three years or more after their initial screen are shown in the table below, categorized by either no immunization or full immunization. Furtherdetail on disease outcomes by birth cohort and time since first screen, stratified by immunisation status will be presented.
Original languageEnglish
Pages283-284
DOIs
Publication statusPublished - Dec 2018
EventEUROGIN 2018 - From control to elimination of HPV induced cancers - Lisbon, Portugal
Duration: 2 Dec 20185 Dec 2018
https://www.eurogin.com/2018/

Conference

ConferenceEUROGIN 2018 - From control to elimination of HPV induced cancers
Abbreviated titleEurogin 2018
Country/TerritoryPortugal
CityLisbon
Period2/12/185/12/18
Internet address

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