Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission

S F Lockett, A Alonso, R Wyld, M P Martin, J R Robertson, S M Gore, C L Leen, R P Brettle, D L Yirrell, M Carrington, A J Brown

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the effect of mutations at the CCR-2 and CCR-5 loci on heterosexual human immunodeficiency virus (HIV) transmission, 144 persons heterosexually exposed to HIV (infected and uninfected [EU]) and 57 HIV-positive index partners were genotyped. A significantly higher frequency of 64I heterozygotes at CCR-2 was observed in HIV-positive than in EU women (P=.02, relative risk=1.6). The allele frequency of 64I in women was 8% in HIV-positive contacts and 1% in EUs (P
Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalThe Journal of Infectious Diseases
Volume180
Issue number3
DOIs
Publication statusPublished - Sep 1999

Keywords

  • Cohort Studies
  • Female
  • Gene Frequency
  • Genotype
  • HIV Infections
  • HIV Seropositivity
  • Heterosexuality
  • Heterozygote
  • Homozygote
  • Humans
  • Male
  • Mutation
  • Polymerase Chain Reaction
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, Chemokine
  • Risk Factors

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