Effect of context exposure after fear learning on memory generalization in mice

Ayano Fujinaka; Ruoshi Li; Masanobu Hayashi; Deependra Kumar; Gopakumar Changarathil; Keisuke Naito; Kousuke Miki; Taihei Nishiyama; Michael Lazarus; Takeshi Sakurai; Nohjin Kee; Satomi Nakajima; Szu-Han Wang; Masanori Sakaguchi

doi:10.1186/s13041-015-0184-0

Effect of context exposure after fear learning on memory generalization in mice

Ayano Fujinaka, Ruoshi Li, Masanobu Hayashi, Deependra Kumar, Gopakumar Changarathil, Keisuke Naito, Kousuke Miki, Taihei Nishiyama, Michael Lazarus, Takeshi Sakurai, Nohjin Kee, Satomi Nakajima, Szu-Han Wang, Masanori Sakaguchi

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Abstract

BACKGROUND: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.

RESULTS: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.

CONCLUSIONS: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.

Original language	English
Pages (from-to)	2
Journal	Molecular Brain
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s13041-015-0184-0
Publication status	Published - 8 Jan 2016

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Szu-Han Wang
- Deanery of Clinical Sciences - Senior Research Fellow
- Centre for Clinical Brain Sciences
- Edinburgh Neuroscience
Person: Academic: Research Active , Academic: Research Active (Research Assistant)

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title = "Effect of context exposure after fear learning on memory generalization in mice",

abstract = "BACKGROUND: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.RESULTS: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.CONCLUSIONS: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.",

author = "Ayano Fujinaka and Ruoshi Li and Masanobu Hayashi and Deependra Kumar and Gopakumar Changarathil and Keisuke Naito and Kousuke Miki and Taihei Nishiyama and Michael Lazarus and Takeshi Sakurai and Nohjin Kee and Satomi Nakajima and Szu-Han Wang and Masanori Sakaguchi",

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T1 - Effect of context exposure after fear learning on memory generalization in mice

AU - Fujinaka, Ayano

AU - Li, Ruoshi

AU - Hayashi, Masanobu

AU - Kumar, Deependra

AU - Changarathil, Gopakumar

AU - Naito, Keisuke

AU - Miki, Kousuke

AU - Nishiyama, Taihei

AU - Lazarus, Michael

AU - Sakurai, Takeshi

AU - Kee, Nohjin

AU - Nakajima, Satomi

AU - Wang, Szu-Han

AU - Sakaguchi, Masanori

PY - 2016/1/8

Y1 - 2016/1/8

N2 - BACKGROUND: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.RESULTS: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.CONCLUSIONS: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.

AB - BACKGROUND: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.RESULTS: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.CONCLUSIONS: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.

U2 - 10.1186/s13041-015-0184-0

DO - 10.1186/s13041-015-0184-0

M3 - Article

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SN - 1756-6606

VL - 9

SP - 2

JO - Molecular Brain

JF - Molecular Brain

IS - 1

ER -

Effect of context exposure after fear learning on memory generalization in mice

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Szu-Han Wang

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