Effect of context exposure after fear learning on memory generalization in mice

Ayano Fujinaka, Ruoshi Li, Masanobu Hayashi, Deependra Kumar, Gopakumar Changarathil, Keisuke Naito, Kousuke Miki, Taihei Nishiyama, Michael Lazarus, Takeshi Sakurai, Nohjin Kee, Satomi Nakajima, Szu-Han Wang, Masanori Sakaguchi

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.

RESULTS: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.

CONCLUSIONS: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.

Original languageEnglish
Pages (from-to)2
JournalMolecular Brain
Issue number1
Publication statusPublished - 8 Jan 2016


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