Effect of major liver resection on hepatic ureagenesis in humans

Marcel C G van de Poll, Stephen J Wigmore, Doris N Redhead, Regina G H Beets-Tan, O James Garden, Jan Willem M Greve, Peter B Soeters, Nicolaas E P Deutz, Kenneth C H Fearon, Cornelis H C Dejong

Research output: Contribution to journalArticlepeer-review

Abstract

Changes in hepatic ureagenesis following major hepatectomy are not well characterized. We studied the relation between urea synthesis and liver mass before and after major hepatectomy in humans. Fifteen patients scheduled for resection of malignancies in otherwise healthy livers were studied. Pre- and postoperative liver volume was assessed by computerized tomography-volumetry. During surgery, a primed, continuous infusion of [(13)C]urea was administered intravenously, and arterial blood samples were obtained hourly. Indocyanine green clearance was determined before and after resection. Seven patients underwent major hepatectomy, and eight patients underwent minor [
Original languageEnglish
Pages (from-to)G956-62
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume293
Issue number5
DOIs
Publication statusPublished - 2007

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