Effect of major liver resection on hepatic ureagenesis in humans

Marcel C G van de Poll; Stephen J Wigmore; Doris N Redhead; Regina G H Beets-Tan; O James Garden; Jan Willem M Greve; Peter B Soeters; Nicolaas E P Deutz; Kenneth C H Fearon; Cornelis H C Dejong

doi:10.1152/ajpgi.00366.2006

Effect of major liver resection on hepatic ureagenesis in humans

Marcel C G van de Poll, Stephen J Wigmore, Doris N Redhead, Regina G H Beets-Tan, O James Garden, Jan Willem M Greve, Peter B Soeters, Nicolaas E P Deutz, Kenneth C H Fearon, Cornelis H C Dejong

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in hepatic ureagenesis following major hepatectomy are not well characterized. We studied the relation between urea synthesis and liver mass before and after major hepatectomy in humans. Fifteen patients scheduled for resection of malignancies in otherwise healthy livers were studied. Pre- and postoperative liver volume was assessed by computerized tomography-volumetry. During surgery, a primed, continuous infusion of [(13)C]urea was administered intravenously, and arterial blood samples were obtained hourly. Indocyanine green clearance was determined before and after resection. Seven patients underwent major hepatectomy, and eight patients underwent minor [

Original language	English
Pages (from-to)	G956-62
Journal	American Journal of Physiology - Gastrointestinal and Liver Physiology
Volume	293
Issue number	5
DOIs	https://doi.org/10.1152/ajpgi.00366.2006
Publication status	Published - 2007

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van de Poll, M. C. G., Wigmore, S. J., Redhead, D. N., Beets-Tan, R. G. H., Garden, O. J., Greve, J. W. M., Soeters, P. B., Deutz, N. E. P., Fearon, K. C. H., & Dejong, C. H. C. (2007). Effect of major liver resection on hepatic ureagenesis in humans. American Journal of Physiology - Gastrointestinal and Liver Physiology, 293(5), G956-62. https://doi.org/10.1152/ajpgi.00366.2006

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title = "Effect of major liver resection on hepatic ureagenesis in humans",

abstract = "Changes in hepatic ureagenesis following major hepatectomy are not well characterized. We studied the relation between urea synthesis and liver mass before and after major hepatectomy in humans. Fifteen patients scheduled for resection of malignancies in otherwise healthy livers were studied. Pre- and postoperative liver volume was assessed by computerized tomography-volumetry. During surgery, a primed, continuous infusion of [(13)C]urea was administered intravenously, and arterial blood samples were obtained hourly. Indocyanine green clearance was determined before and after resection. Seven patients underwent major hepatectomy, and eight patients underwent minor [",

author = "{van de Poll}, {Marcel C G} and Wigmore, {Stephen J} and Redhead, {Doris N} and Beets-Tan, {Regina G H} and Garden, {O James} and Greve, {Jan Willem M} and Soeters, {Peter B} and Deutz, {Nicolaas E P} and Fearon, {Kenneth C H} and Dejong, {Cornelis H C}",

year = "2007",

doi = "10.1152/ajpgi.00366.2006",

language = "English",

volume = "293",

pages = "G956--62",

journal = "American Journal of Physiology - Gastrointestinal and Liver Physiology",

issn = "0193-1857",

publisher = "American Physiological Society",

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T1 - Effect of major liver resection on hepatic ureagenesis in humans

AU - van de Poll, Marcel C G

AU - Wigmore, Stephen J

AU - Redhead, Doris N

AU - Beets-Tan, Regina G H

AU - Garden, O James

AU - Greve, Jan Willem M

AU - Soeters, Peter B

AU - Deutz, Nicolaas E P

AU - Fearon, Kenneth C H

AU - Dejong, Cornelis H C

PY - 2007

Y1 - 2007

N2 - Changes in hepatic ureagenesis following major hepatectomy are not well characterized. We studied the relation between urea synthesis and liver mass before and after major hepatectomy in humans. Fifteen patients scheduled for resection of malignancies in otherwise healthy livers were studied. Pre- and postoperative liver volume was assessed by computerized tomography-volumetry. During surgery, a primed, continuous infusion of [(13)C]urea was administered intravenously, and arterial blood samples were obtained hourly. Indocyanine green clearance was determined before and after resection. Seven patients underwent major hepatectomy, and eight patients underwent minor [

AB - Changes in hepatic ureagenesis following major hepatectomy are not well characterized. We studied the relation between urea synthesis and liver mass before and after major hepatectomy in humans. Fifteen patients scheduled for resection of malignancies in otherwise healthy livers were studied. Pre- and postoperative liver volume was assessed by computerized tomography-volumetry. During surgery, a primed, continuous infusion of [(13)C]urea was administered intravenously, and arterial blood samples were obtained hourly. Indocyanine green clearance was determined before and after resection. Seven patients underwent major hepatectomy, and eight patients underwent minor [

U2 - 10.1152/ajpgi.00366.2006

DO - 10.1152/ajpgi.00366.2006

M3 - Article

C2 - 17717046

VL - 293

SP - G956-62

JO - American Journal of Physiology - Gastrointestinal and Liver Physiology

JF - American Journal of Physiology - Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 5

ER -

Effect of major liver resection on hepatic ureagenesis in humans

Abstract

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