Effect of Right Insular Involvement on Death and Functional Outcome after Acute Ischemic Stroke in the IST-3 Trial

Luciano A. Sposato, Geoffrey Cohen, Joanna M. Wardlaw, Peter Sandercock, Richard I. Lindley, Vladimir Hachinski, IST-3 Expert Reading Panel, IST-3 Collaborative Grp

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Background and Purpose—In patients with acute ischemic stroke, whether involvement of the insular cortex influences outcome is controversial. Much of the apparent adverse outcome may relate to such strokes usually being severe. We examined the influence of right and left insular involvement on stroke outcomes among patients from the Third International Stroke Trial (IST-3) who had visible ischemic stroke on neuroimaging.
Methods—We used multiple logistic regression to compare outcomes of left vs. right insular and non-insular strokes across strata of stroke severity, on death, proportion dead or dependent, and level of disability (ordinalized Oxford Handicap Score) at 6 months, with adjustment for the effects of age, lesion size, and presence of atrial fibrillation .
Results—Of 3,035 patients recruited, 2,099 had visible ischemic strokes limited to a single hemisphere on CT/MR scans. Of these, 566 and 714 had infarction of right and left insula. Six months after randomization, right insular involvement was associated with increased odds of death as compared with non-insular strokes on the left side (adjusted odds ratio [OR] 1.83, 95%CI 1.33−2.52), whereas the adjusted OR comparing mortality following insular vs. non-insular strokes on the left side was not significant. Among mild/moderate strokes, outcomes for right insular involvement were worse than for left insular, but among more severe strokes the difference in outcomes was less substantial.
Conclusions—We found an association between right insular involvement and higher odds of death and worse functional outcome. The difference between right- and left-sided insular lesions on outcomes seemed to be most evident for mild/moderate strokes.
Original languageEnglish
Pages (from-to)2959-2965
Number of pages7
Issue number12
Early online date15 Nov 2016
Publication statusPublished - Dec 2016


  • cerebral infarction
  • death
  • functional laterality
  • insula
  • insular cortex
  • prognosis
  • stroke

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