Effect of the BDNF V166M polymorphism on working memory in healthy adolescents

N. K. Hansell; M. R. James; D. L. Duffy; A. J. Birley; M. Luciano; G. M. Geffen; M. J. Wright; G. W. Montgomery; N. G. Martin

Effect of the BDNF V166M polymorphism on working memory in healthy adolescents

N. K. Hansell, M. R. James, D. L. Duffy, A. J. Birley, M. Luciano, G. M. Geffen, M. J. Wright, G. W. Montgomery, N. G. Martin

School of Philosophy, Psychology and Language Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (alpha = 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.

Original language	English
Pages (from-to)	260-268
Number of pages	9
Journal	Genes, Brain and Behavior
Volume	6
Issue number	3
Publication status	Published - Apr 2007

Keywords

delayed-response
event-related potentials
genes
QTDT
twins
FACTOR VAL66MET POLYMORPHISM
ACTIVITY-DEPENDENT SECRETION
FAMILY-BASED ASSOCIATION
NEUROTROPHIC FACTOR GENE
HIPPOCAMPAL-FORMATION
PREFRONTAL CORTEX
EPISODIC MEMORY
ENDOGENOUS POTENTIALS
BDNF POLYMORPHISM
BIPOLAR DISORDER

Cite this

@article{719f5cdd61dd4b2c93d5d6a37414c557,

title = "Effect of the BDNF V166M polymorphism on working memory in healthy adolescents",

abstract = "Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (alpha = 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.",

keywords = "delayed-response, event-related potentials, genes, QTDT, twins, FACTOR VAL66MET POLYMORPHISM, ACTIVITY-DEPENDENT SECRETION, FAMILY-BASED ASSOCIATION, NEUROTROPHIC FACTOR GENE, HIPPOCAMPAL-FORMATION, PREFRONTAL CORTEX, EPISODIC MEMORY, ENDOGENOUS POTENTIALS, BDNF POLYMORPHISM, BIPOLAR DISORDER",

author = "Hansell, {N. K.} and James, {M. R.} and Duffy, {D. L.} and Birley, {A. J.} and M. Luciano and Geffen, {G. M.} and Wright, {M. J.} and Montgomery, {G. W.} and Martin, {N. G.}",

year = "2007",

month = apr,

language = "English",

volume = "6",

pages = "260--268",

journal = "Genes, Brain and Behavior",

issn = "1601-1848",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Effect of the BDNF V166M polymorphism on working memory in healthy adolescents

AU - Hansell, N. K.

AU - James, M. R.

AU - Duffy, D. L.

AU - Birley, A. J.

AU - Luciano, M.

AU - Geffen, G. M.

AU - Wright, M. J.

AU - Montgomery, G. W.

AU - Martin, N. G.

PY - 2007/4

Y1 - 2007/4

N2 - Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (alpha = 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.

AB - Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (alpha = 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.

KW - delayed-response

KW - event-related potentials

KW - genes

KW - QTDT

KW - twins

KW - FACTOR VAL66MET POLYMORPHISM

KW - ACTIVITY-DEPENDENT SECRETION

KW - FAMILY-BASED ASSOCIATION

KW - NEUROTROPHIC FACTOR GENE

KW - HIPPOCAMPAL-FORMATION

KW - PREFRONTAL CORTEX

KW - EPISODIC MEMORY

KW - ENDOGENOUS POTENTIALS

KW - BDNF POLYMORPHISM

KW - BIPOLAR DISORDER

M3 - Article

VL - 6

SP - 260

EP - 268

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

IS - 3

ER -

Effect of the BDNF V166M polymorphism on working memory in healthy adolescents

Abstract

Keywords

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