Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis

A J Lucking; A Visvanathan; H Philippou; S Fraser; P J Grant; T M Connolly; S J Gardell; G Z Feuerstein; K A A Fox; N A Booth; D E Newby

doi:10.1111/j.1538-7836.2010.03872.x

Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis

A J Lucking, A Visvanathan, H Philippou, S Fraser, P J Grant, T M Connolly, S J Gardell, G Z Feuerstein, K A A Fox, N A Booth, D E Newby

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The principal inhibitor of fibrinolysis in vivo is plasminogen activator inhibitor-1 (PAI-1). PAI-749 is a small molecule inhibitor of PAI-1 with proven antithrombotic efficacy in several preclinical models.

Original language	English
Pages (from-to)	1333-9
Number of pages	7
Journal	Journal of Thrombosis and Haemostasis
Volume	8
Issue number	6
DOIs	https://doi.org/10.1111/j.1538-7836.2010.03872.x
Publication status	Published - 2010

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Lucking, A. J., Visvanathan, A., Philippou, H., Fraser, S., Grant, P. J., Connolly, T. M., Gardell, S. J., Feuerstein, G. Z., Fox, K. A. A., Booth, N. A., & Newby, D. E. (2010). Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. Journal of Thrombosis and Haemostasis, 8(6), 1333-9. https://doi.org/10.1111/j.1538-7836.2010.03872.x

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title = "Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis",

abstract = "The principal inhibitor of fibrinolysis in vivo is plasminogen activator inhibitor-1 (PAI-1). PAI-749 is a small molecule inhibitor of PAI-1 with proven antithrombotic efficacy in several preclinical models.",

author = "Lucking, {A J} and A Visvanathan and H Philippou and S Fraser and Grant, {P J} and Connolly, {T M} and Gardell, {S J} and Feuerstein, {G Z} and Fox, {K A A} and Booth, {N A} and Newby, {D E}",

year = "2010",

doi = "10.1111/j.1538-7836.2010.03872.x",

language = "English",

volume = "8",

pages = "1333--9",

journal = "Journal of Thrombosis and Haemostasis",

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Lucking, AJ, Visvanathan, A, Philippou, H, Fraser, S, Grant, PJ, Connolly, TM, Gardell, SJ, Feuerstein, GZ, Fox, KAA, Booth, NA & Newby, DE 2010, 'Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis', Journal of Thrombosis and Haemostasis, vol. 8, no. 6, pp. 1333-9. https://doi.org/10.1111/j.1538-7836.2010.03872.x

TY - JOUR

T1 - Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis

AU - Lucking, A J

AU - Visvanathan, A

AU - Philippou, H

AU - Fraser, S

AU - Grant, P J

AU - Connolly, T M

AU - Gardell, S J

AU - Feuerstein, G Z

AU - Fox, K A A

AU - Booth, N A

AU - Newby, D E

PY - 2010

Y1 - 2010

N2 - The principal inhibitor of fibrinolysis in vivo is plasminogen activator inhibitor-1 (PAI-1). PAI-749 is a small molecule inhibitor of PAI-1 with proven antithrombotic efficacy in several preclinical models.

AB - The principal inhibitor of fibrinolysis in vivo is plasminogen activator inhibitor-1 (PAI-1). PAI-749 is a small molecule inhibitor of PAI-1 with proven antithrombotic efficacy in several preclinical models.

UR - http://www.scopus.com/inward/record.url?scp=77954484040&partnerID=8YFLogxK

U2 - 10.1111/j.1538-7836.2010.03872.x

DO - 10.1111/j.1538-7836.2010.03872.x

M3 - Article

C2 - 20345708

SN - 1538-7933

VL - 8

SP - 1333

EP - 1339

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 6

ER -

Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis

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