Effect of two anaesthetic regimens on airway nitric oxide production in horses

DJ Marlin*, LE Young, R McMurphy, K Walsh, P Dixon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


There is evidence that halothane inhibits nitric oxide synthase in vitro, but the effect of intravenous anaesthetic agents is less clear. This study was undertaken to compare the rate of exhaled nitric oxide production ((V) over dot (NO)) in spontaneously breathing horses anaesthetized with halothane or an intravenous regimen. Seven adult horses were studied twice in random order. After premedication with romifidine 100 mug kg(-1), anaesthesia was induced with ketamine 2.2 mg kg(-1) and maintained with halothane in oxygen (HA) or by an intravenous infusion of ketamine, guaiphenesin and romifrdine (IV). Inhaled and exhaled nitric oxide (NO) concentrations, respiratory minute ventilation (VE), pulmonary artery pressure (PPA), fractional inspired oxygen concentration (FIO2), end-tidal carbon dioxide concentration (E'(CO2)), cardiac output ((Q) over dot) and partial pressures of oxygen and carbon dioxide in arterial blood (Pao,, Pace,) were measured. Exhaled nitric oxide production rate was significantly lower (40 min, P

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number1
Publication statusPublished - Jan 2001


  • horse
  • anaesthesia
  • pharmacology, nitric oxide
  • anaesthetics volatile, halothane


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