Abstract / Description of output
There is evidence that halothane inhibits nitric oxide synthase in vitro, but the effect of intravenous anaesthetic agents is less clear. This study was undertaken to compare the rate of exhaled nitric oxide production ((V) over dot (NO)) in spontaneously breathing horses anaesthetized with halothane or an intravenous regimen. Seven adult horses were studied twice in random order. After premedication with romifidine 100 mug kg(-1), anaesthesia was induced with ketamine 2.2 mg kg(-1) and maintained with halothane in oxygen (HA) or by an intravenous infusion of ketamine, guaiphenesin and romifrdine (IV). Inhaled and exhaled nitric oxide (NO) concentrations, respiratory minute ventilation (VE), pulmonary artery pressure (PPA), fractional inspired oxygen concentration (FIO2), end-tidal carbon dioxide concentration (E'(CO2)), cardiac output ((Q) over dot) and partial pressures of oxygen and carbon dioxide in arterial blood (Pao,, Pace,) were measured. Exhaled nitric oxide production rate was significantly lower (40 min, P
Original language | English |
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Pages (from-to) | 127-130 |
Number of pages | 4 |
Journal | British Journal of Anaesthesia |
Volume | 86 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2001 |
Keywords / Materials (for Non-textual outputs)
- horse
- anaesthesia
- pharmacology, nitric oxide
- anaesthetics volatile, halothane
- THOROUGHBRED HORSES
- HALOTHANE
- EXERCISE