Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes

D A Cameron; J C Keen; J M Dixon; C Bellamy; A Hanby; T J Anderson; W R Miller

Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes

D A Cameron, J C Keen, J M Dixon, C Bellamy, A Hanby, T J Anderson, W R Miller

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Despite knowledge of oestrogen receptor status, it is not always possible to predict which breast cancers will respond to tamoxifen. We have previously reported that decreased expression of Bcl-2 and/or Ki-S1 were associated with tumour response to neo-adjuvant tamoxifen in 50 elderly women with oestrogen receptor (ER)-positive breast cancer. In this study, we confirm that the expression of Bcl-2 and Ki-S1 are surrogates for the frequency of apoptosis and mitosis respectively, within these untreated breast cancers, with an inverse relationship between Bcl-2 expression and the apoptotic index (P

Original language	English
Pages (from-to)	845-51
Number of pages	7
Journal	European Journal of Cancer
Volume	36
Issue number	7
Publication status	Published - May 2000

Keywords / Materials (for Non-textual outputs)

Aged
Aged, 80 and over
Antigens, Neoplasm
Apoptosis
Breast Neoplasms
Cell Division
DNA Topoisomerases, Type II
DNA-Binding Proteins
Female
Humans
Immunohistochemistry
Mitosis
Nuclear Proteins
Proto-Oncogene Proteins c-bcl-2
Tamoxifen
Time Factors
Tumor Markers, Biological

Cite this

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title = "Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes",

abstract = "Despite knowledge of oestrogen receptor status, it is not always possible to predict which breast cancers will respond to tamoxifen. We have previously reported that decreased expression of Bcl-2 and/or Ki-S1 were associated with tumour response to neo-adjuvant tamoxifen in 50 elderly women with oestrogen receptor (ER)-positive breast cancer. In this study, we confirm that the expression of Bcl-2 and Ki-S1 are surrogates for the frequency of apoptosis and mitosis respectively, within these untreated breast cancers, with an inverse relationship between Bcl-2 expression and the apoptotic index (P",

keywords = "Aged, Aged, 80 and over, Antigens, Neoplasm, Apoptosis, Breast Neoplasms, Cell Division, DNA Topoisomerases, Type II, DNA-Binding Proteins, Female, Humans, Immunohistochemistry, Mitosis, Nuclear Proteins, Proto-Oncogene Proteins c-bcl-2, Tamoxifen, Time Factors, Tumor Markers, Biological",

author = "Cameron, {D A} and Keen, {J C} and Dixon, {J M} and C Bellamy and A Hanby and Anderson, {T J} and Miller, {W R}",

year = "2000",

month = may,

language = "English",

volume = "36",

pages = "845--51",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Pergamon Press",

number = "7",

}

TY - JOUR

T1 - Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes

AU - Cameron, D A

AU - Keen, J C

AU - Dixon, J M

AU - Bellamy, C

AU - Hanby, A

AU - Anderson, T J

AU - Miller, W R

PY - 2000/5

Y1 - 2000/5

N2 - Despite knowledge of oestrogen receptor status, it is not always possible to predict which breast cancers will respond to tamoxifen. We have previously reported that decreased expression of Bcl-2 and/or Ki-S1 were associated with tumour response to neo-adjuvant tamoxifen in 50 elderly women with oestrogen receptor (ER)-positive breast cancer. In this study, we confirm that the expression of Bcl-2 and Ki-S1 are surrogates for the frequency of apoptosis and mitosis respectively, within these untreated breast cancers, with an inverse relationship between Bcl-2 expression and the apoptotic index (P

AB - Despite knowledge of oestrogen receptor status, it is not always possible to predict which breast cancers will respond to tamoxifen. We have previously reported that decreased expression of Bcl-2 and/or Ki-S1 were associated with tumour response to neo-adjuvant tamoxifen in 50 elderly women with oestrogen receptor (ER)-positive breast cancer. In this study, we confirm that the expression of Bcl-2 and Ki-S1 are surrogates for the frequency of apoptosis and mitosis respectively, within these untreated breast cancers, with an inverse relationship between Bcl-2 expression and the apoptotic index (P

KW - Aged

KW - Aged, 80 and over

KW - Antigens, Neoplasm

KW - Apoptosis

KW - Breast Neoplasms

KW - Cell Division

KW - DNA Topoisomerases, Type II

KW - DNA-Binding Proteins

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Mitosis

KW - Nuclear Proteins

KW - Proto-Oncogene Proteins c-bcl-2

KW - Tamoxifen

KW - Time Factors

KW - Tumor Markers, Biological

M3 - Article

C2 - 10785588

SN - 0959-8049

VL - 36

SP - 845

EP - 851

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 7

ER -

Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes

Abstract

Keywords / Materials (for Non-textual outputs)

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