Effectiveness and safety of coronavirus disease 2019 vaccines

Ting Shi, Chris Robertson, Aziz Sheikh

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

PURPOSE OF REVIEW: To review and summarise recent evidence on the effectiveness of coronavirus disease 2019 (COVID-19) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 hospitalisation and death in adults as well as in specific population groups, namely pregnant women, and children and adolescents. We also sought to summarise evidence on vaccine safety in relation to cardiovascular and neurological complications. In order to do so, we drew primarily on evidence from two our own data platforms and supplement these with insights from related large population-based studies and systematic reviews.

RECENT FINDINGS: All studies showed high vaccine effectiveness against confirmed SARS-CoV-2 infection and in particular against COVID-19 hospitalisation and death. However, vaccine effectiveness against symptomatic COVID-19 infection waned over time. These studies also found that booster vaccines would be needed to maintain high vaccine effectiveness against severe COVID-19 outcomes. Rare cardiovascular and neurological complications have been reported in association with COVID-19 vaccines.

SUMMARY: The findings from this paper support current recommendations that vaccination remains the safest way for adults, pregnant women, children and adolescents to be protected against COVID-19. There is a need to continue to monitor the effectiveness and safety of COVID-19 vaccines as these continue to be deployed in the evolving pandemic.

Original languageEnglish
Pages (from-to)138-142
JournalCurrent opinion in pulmonary medicine
Issue number3
Early online date27 Feb 2023
Publication statusPublished - 1 May 2023

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • COVID-19 Vaccines/adverse effects
  • COVID-19/prevention & control
  • Child
  • Dietary Supplements
  • Female
  • Hospitalization
  • Humans
  • Pregnancy
  • SARS-CoV-2


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