Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women

Vivian Brache; Regine Sitruk-Ware; Alistair Williams; Diana Blithe; Horacio Croxatto; Narender Kumar; Sushma Kumar; Yun-Yen Tsong; Irving Sivin; Anita Nath; Heather Sussman; Leila Cochon; Maria Jose Miranda; Verónica Reyes; Anibal Faundes; Daniel Mishell

doi:10.1016/j.contraception.2011.10.003

Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women

Vivian Brache, Regine Sitruk-Ware, Alistair Williams, Diana Blithe, Horacio Croxatto, Narender Kumar, Sushma Kumar, Yun-Yen Tsong, Irving Sivin, Anita Nath, Heather Sussman, Leila Cochon, Maria Jose Miranda, Verónica Reyes, Anibal Faundes, Daniel Mishell

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Progesterone receptor modulators (PRMs) delivered by contraceptive vaginal rings provide an opportunity for development of an estrogen-free contraceptive that does not require daily oral intake of steroids. The objective of this proof-of-concept study was to determine whether continuous delivery of 600-800 mcg of ulipristal acetate (UPA) from a contraceptive vaginal ring could achieve 80% to 90% inhibition of ovulation.

Original language	English
Pages (from-to)	480-8
Number of pages	9
Journal	Contraception
Volume	85
Issue number	5
DOIs	https://doi.org/10.1016/j.contraception.2011.10.003
Publication status	Published - 2012

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10.1016/j.contraception.2011.10.003

Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation
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http://www.sciencedirect.com/science/article/pii/S0010782411005762

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Brache, V., Sitruk-Ware, R., Williams, A., Blithe, D., Croxatto, H., Kumar, N., Kumar, S., Tsong, Y-Y., Sivin, I., Nath, A., Sussman, H., Cochon, L., Miranda, M. J., Reyes, V., Faundes, A., & Mishell, D. (2012). Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women. Contraception, 85(5), 480-8. https://doi.org/10.1016/j.contraception.2011.10.003

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abstract = "Progesterone receptor modulators (PRMs) delivered by contraceptive vaginal rings provide an opportunity for development of an estrogen-free contraceptive that does not require daily oral intake of steroids. The objective of this proof-of-concept study was to determine whether continuous delivery of 600-800 mcg of ulipristal acetate (UPA) from a contraceptive vaginal ring could achieve 80% to 90% inhibition of ovulation.",

author = "Vivian Brache and Regine Sitruk-Ware and Alistair Williams and Diana Blithe and Horacio Croxatto and Narender Kumar and Sushma Kumar and Yun-Yen Tsong and Irving Sivin and Anita Nath and Heather Sussman and Leila Cochon and Miranda, {Maria Jose} and Ver{\'o}nica Reyes and Anibal Faundes and Daniel Mishell",

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Brache, V, Sitruk-Ware, R, Williams, A, Blithe, D, Croxatto, H, Kumar, N, Kumar, S, Tsong, Y-Y, Sivin, I, Nath, A, Sussman, H, Cochon, L, Miranda, MJ, Reyes, V, Faundes, A & Mishell, D 2012, 'Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women', Contraception, vol. 85, no. 5, pp. 480-8. https://doi.org/10.1016/j.contraception.2011.10.003

TY - JOUR

T1 - Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women

AU - Brache, Vivian

AU - Sitruk-Ware, Regine

AU - Williams, Alistair

AU - Blithe, Diana

AU - Croxatto, Horacio

AU - Kumar, Narender

AU - Kumar, Sushma

AU - Tsong, Yun-Yen

AU - Sivin, Irving

AU - Nath, Anita

AU - Sussman, Heather

AU - Cochon, Leila

AU - Miranda, Maria Jose

AU - Reyes, Verónica

AU - Faundes, Anibal

AU - Mishell, Daniel

PY - 2012

Y1 - 2012

N2 - Progesterone receptor modulators (PRMs) delivered by contraceptive vaginal rings provide an opportunity for development of an estrogen-free contraceptive that does not require daily oral intake of steroids. The objective of this proof-of-concept study was to determine whether continuous delivery of 600-800 mcg of ulipristal acetate (UPA) from a contraceptive vaginal ring could achieve 80% to 90% inhibition of ovulation.

AB - Progesterone receptor modulators (PRMs) delivered by contraceptive vaginal rings provide an opportunity for development of an estrogen-free contraceptive that does not require daily oral intake of steroids. The objective of this proof-of-concept study was to determine whether continuous delivery of 600-800 mcg of ulipristal acetate (UPA) from a contraceptive vaginal ring could achieve 80% to 90% inhibition of ovulation.

U2 - 10.1016/j.contraception.2011.10.003

DO - 10.1016/j.contraception.2011.10.003

M3 - Article

C2 - 22176795

VL - 85

SP - 480

EP - 488

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 5

ER -

Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women

Abstract

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