Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure

N E Goodfield, D E Newby, C A Ludlam, A D Flapan

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Angiotensin converting enzyme (ACE) inhibition after myocardial infarction is associated with an improvement in plasma fibrinolytic parameters. The aim of the present study was to determine whether acute ACE inhibition and angiotensin II type 1 (AT1) receptor antagonism have similar effects in patients with heart failure.

METHODS AND RESULTS: Twenty patients with moderately severe chronic heart failure received enalapril 10 mg and losartan 50 mg on 2 separate occasions in a single-blind, randomized, crossover design. Plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) antigen and activity were measured at baseline and 6 hours after the dose. Acute administration of losartan but not of enalapril reduced plasma t-PA (11%; P=0.003) and PAI-1 (38%; P<0.001) antigen concentrations, which was associated with increases in t-PA (29%; P=0.03) and decreases in PAI-1 (48%; P=0.01) activity. Changes in plasma fibrinolytic parameters were more marked during losartan treatment (P<0.02), with a 3-fold greater reduction in plasma PAI-1 antigen concentrations (P<0.05).

CONCLUSIONS: Acute AT1 antagonism in patients with heart failure is associated with a significant improvement in plasma fibrinolytic parameters that is greater than during ACE inhibition. These beneficial effects of AT1 antagonism and ACE inhibition would therefore appear to be mediated principally through suppression of angiotensin II.

Original languageEnglish
Pages (from-to)2983-5
Number of pages3
JournalCirculation
Volume99
Issue number23
Publication statusPublished - 15 Jun 1999

Keywords

  • Aged
  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Atrial Natriuretic Factor
  • Blood Pressure
  • Cardiomyopathy, Dilated
  • Cross-Over Studies
  • Enalapril
  • Female
  • Fibrinolysis
  • Heart Failure
  • Heart Rate
  • Hemodynamics
  • Humans
  • Losartan
  • Male
  • Myocardial Ischemia
  • Plasminogen Activator Inhibitor 1
  • Receptor, Angiotensin, Type 1
  • Receptor, Angiotensin, Type 2
  • Single-Blind Method
  • Tissue Plasminogen Activator
  • Ventricular Dysfunction, Left

Fingerprint

Dive into the research topics of 'Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure'. Together they form a unique fingerprint.

Cite this