Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring

UK Collaborative HIV Cohort Study; Alan Winston; Sophie Jose; Sara Gibbons; David Back; Wolfgang Stohr; Frank Post; Martin Fisher; Brian Gazzard; Mark Nelson; Richard Gilson; Chloe Orkin; Margaret Johnson; Adrian Palfreeman; David Chadwick; Clifford Leen; Achim Schwenk; Jane Anderson; Mark Gompels; David Dunn; Saye Khoo; Caroline Sabin

doi:10.1093/jac/dkt029

Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring

UK Collaborative HIV Cohort Study, Alan Winston, Sophie Jose, Sara Gibbons, David Back, Wolfgang Stohr, Frank Post, Martin Fisher, Brian Gazzard, Mark Nelson, Richard Gilson, Chloe Orkin, Margaret Johnson, Adrian Palfreeman, David Chadwick, Clifford Leen, Achim Schwenk, Jane Anderson, Mark Gompels, David DunnSaye Khoo, Caroline Sabin

College of Medicine and Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The pharmacokinetic and pharmacodynamic effects of antiretroviral therapy may differ in older compared with younger subjects with HIV infection. We aimed to assess factors associated with plasma antiretroviral drug exposure, including age, within a large HIV-infected cohort undergoing therapeutic drug monitoring (TDM).

Original language	English
Pages (from-to)	1354-9
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	68
Issue number	6
DOIs	https://doi.org/10.1093/jac/dkt029
Publication status	Published - Jun 2013

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10.1093/jac/dkt029

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UK Collaborative HIV Cohort Study, Winston, A., Jose, S., Gibbons, S., Back, D., Stohr, W., Post, F., Fisher, M., Gazzard, B., Nelson, M., Gilson, R., Orkin, C., Johnson, M., Palfreeman, A., Chadwick, D., Leen, C., Schwenk, A., Anderson, J., Gompels, M., ... Sabin, C. (2013). Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring. Journal of Antimicrobial Chemotherapy, 68(6), 1354-9. https://doi.org/10.1093/jac/dkt029

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title = "Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring",

abstract = "The pharmacokinetic and pharmacodynamic effects of antiretroviral therapy may differ in older compared with younger subjects with HIV infection. We aimed to assess factors associated with plasma antiretroviral drug exposure, including age, within a large HIV-infected cohort undergoing therapeutic drug monitoring (TDM).",

author = "\{UK Collaborative HIV Cohort Study\} and Alan Winston and Sophie Jose and Sara Gibbons and David Back and Wolfgang Stohr and Frank Post and Martin Fisher and Brian Gazzard and Mark Nelson and Richard Gilson and Chloe Orkin and Margaret Johnson and Adrian Palfreeman and David Chadwick and Clifford Leen and Achim Schwenk and Jane Anderson and Mark Gompels and David Dunn and Saye Khoo and Caroline Sabin",

year = "2013",

month = jun,

doi = "10.1093/jac/dkt029",

language = "English",

volume = "68",

pages = "1354--9",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "1460-2091",

publisher = "Oxford University Press",

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UK Collaborative HIV Cohort Study, Winston, A, Jose, S, Gibbons, S, Back, D, Stohr, W, Post, F, Fisher, M, Gazzard, B, Nelson, M, Gilson, R, Orkin, C, Johnson, M, Palfreeman, A, Chadwick, D, Leen, C, Schwenk, A, Anderson, J, Gompels, M, Dunn, D, Khoo, S & Sabin, C 2013, 'Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring', Journal of Antimicrobial Chemotherapy, vol. 68, no. 6, pp. 1354-9. https://doi.org/10.1093/jac/dkt029

TY - JOUR

T1 - Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring

AU - UK Collaborative HIV Cohort Study

AU - Winston, Alan

AU - Jose, Sophie

AU - Gibbons, Sara

AU - Back, David

AU - Stohr, Wolfgang

AU - Post, Frank

AU - Fisher, Martin

AU - Gazzard, Brian

AU - Nelson, Mark

AU - Gilson, Richard

AU - Orkin, Chloe

AU - Johnson, Margaret

AU - Palfreeman, Adrian

AU - Chadwick, David

AU - Leen, Clifford

AU - Schwenk, Achim

AU - Anderson, Jane

AU - Gompels, Mark

AU - Dunn, David

AU - Khoo, Saye

AU - Sabin, Caroline

PY - 2013/6

Y1 - 2013/6

N2 - The pharmacokinetic and pharmacodynamic effects of antiretroviral therapy may differ in older compared with younger subjects with HIV infection. We aimed to assess factors associated with plasma antiretroviral drug exposure, including age, within a large HIV-infected cohort undergoing therapeutic drug monitoring (TDM).

AB - The pharmacokinetic and pharmacodynamic effects of antiretroviral therapy may differ in older compared with younger subjects with HIV infection. We aimed to assess factors associated with plasma antiretroviral drug exposure, including age, within a large HIV-infected cohort undergoing therapeutic drug monitoring (TDM).

U2 - 10.1093/jac/dkt029

DO - 10.1093/jac/dkt029

M3 - Article

C2 - 23435690

SN - 1460-2091

VL - 68

SP - 1354

EP - 1359

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 6

ER -

Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring

Abstract

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