Effects of alcohol on placental growth and Igf 2 expression

Teodora Taseva, Yana Koycheva, Nelly Olova, Steliyana Popova, Leonid Penkov

Research output: Contribution to journalArticlepeer-review

Abstract

The pre-implantation stage of mouse embryo development is characterised with a peak of epigenetic reprogramming, which is sensitive to the harmful effects of acute doses of alcohol. We previously demonstrated that ethanol reduces weight and alters Igf2 expression in the developing embryo. The objective of the present study was to investigate the effects of 2.9 and 5.8 g/kg ethanol on the placenta. The ethanol was applied at 3.5 and 4.5 dpc on pregnant mice from the C57BL/6 strain. At 11.5 dpc we examined placental weight, as well as the expression from P0, P1, P2, and P3 promoters of the imprinted gene Igf2. We observed that the 2.9 g/kg dose altered P0 and P1 expression, while 5.8 g/kg ethanol down-regulated all four Igf2 promoters. Both doses lead to placental growth restriction.

Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalComptes Rendus de L'Academie Bulgare des Sciences
Volume68
Issue number9
Publication statusPublished - 2015

Keywords

  • Ethanol
  • Foetal alcohol syndrome
  • Imprinted genes
  • Mouse placenta

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